Patents Assigned to Dart NeuroScience (Cayman) Ltd.
  • Pyrazole compounds and uses thereof
    Patent number: 8399487
    Abstract: The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 19, 2013
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventors: Xianbo Zhou, Roderick E. M. Scott, Rusiko Bourtchouladze, Alan P. Kaplan, Terence P. Keenan, Andrew McRiner
  • Therapeutic pyrazoloquinoline urea derivatives
    Patent number: 8343957
    Abstract: The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: January 1, 2013
    Assignee: Dart Neuroscience (Cayman) Ltd.
    Inventors: Alan P. Kaplan, Varsha Gupta
  • Enteric-coated HT-2157 compositions and methods of their use
    Patent number: 8277842
    Abstract: Drug compositions comprising the compound HT-2157 and their therapeutic uses, including the treatment of CNS disorders and cognitive impairments and the modulation of cognitive function, are disclosed. More particularly, the present invention relates to enteric-coated formulations comprising HT-2157 that reduce the appearance of clinically relevant methemoglobinemia relative to administration of non-enteric-coated formulations comprising HT-2157.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: October 2, 2012
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventor: Alan P Kaplan
  • THERAPEUTIC ISOXAZOLE COMPOUNDS
    Publication number: 20120202786
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Application
    Filed: April 16, 2012
    Publication date: August 9, 2012
    Applicant: Dart Neuroscience (Cayman) Ltd.
    Inventors: Alan P. Kaplan, Terence P. Keenan, Andrew J. McRiner
  • Therapeutic isoxazole compounds
    Patent number: 8222243
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: July 17, 2012
    Assignee: Dart NeuroScience (Cayman) Ltd
    Inventors: Alan P. Kaplan, Terence P. Keenan, Andrew J. McRiner
  • Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
    Patent number: 8153646
    Abstract: The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: April 10, 2012
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventors: Thomas M. Hallam, Tim Tully, Rusiko Bourtchouladze