Patents Assigned to Dartsbio Pharmaceuticals Ltd.
  • B7-H3 NANOBODY, PREPARATION METHOD AND USE THEREOF
    Publication number: 20240092910
    Abstract: The present invention provides a B7-H3 nanobody, the preparation method and use thereof. The B7-H3 nanobody comprises framework regions 1-4 (FR 1-4) and complementarity determining regions 1-3 (CDR 1-3), can specifically bind to B7-H3, and can be used for detecting B7-H3 molecules, and be used for the treatment of various malignant tumors with abnormal expression of B7-H3 molecule.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 21, 2024
    Applicants: Dartsbio Pharmaceuticals Ltd., Shanghai Mabstone Biotechnology Ltd., Shenzhen Innovastone Biopharma Ltd.
    Inventors: Chunhe WANG, Yi-li CHEN, Xinyuan LIU, Weidong LUO, Guojian LIU, Huanhuan LI, Yijun LIN
  • USE OF NGF ANTIBODY IN CIPN PAIN
    Publication number: 20240009304
    Abstract: Provided is use of an NGF antibody in CIPN pain. In particular, the NGF antibody blocks the interaction of nerve growth factors (NGF) with receptors thereof, and thus can treat and/or prevent chemotherapy-induced peripheral neuropathy (CIPN) pain.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 11, 2024
    Applicants: Dartsbio Pharmaceuticals Ltd., Shanghai Mabstone Biotechnology Co., Ltd.
    Inventors: Chunhe WANG, Zuobin XIE, Huaping DING, Yili CHEN, Huanhuan LI, Lei TANG
  • INTERMEDIATE FOR PREPARING ANTIBODY-DRUG CONJUGATE (ADC), PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20230346969
    Abstract: Provided are an intermediate (connexon and load combination) for preparing an antibody-drug conjugate (ADC), a preparation method therefor, and the use thereof. The connexon and load combination has a structure as represented by formula I. Formula I can be used for coupling highly hydrophobic compound loads, such as paclitaxel (PTX’), and a prepared ADC molecule has good hydrophilicity and thermal stability and can achieve a higher drug-to-antibody ratio.
    Type: Application
    Filed: June 18, 2021
    Publication date: November 2, 2023
    Applicant: Dartsbio Pharmaceuticals Ltd.
    Inventors: Chunhe WANG, Ting SHAO, Tianzhi CHEN, Qi WANG, Yili CHEN, Yijun LIN