Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-? binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.
Type:
Grant
Filed:
February 27, 2004
Date of Patent:
July 20, 2010
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
Abstract: Antibodies to a novel family of TGF-? binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.
Type:
Grant
Filed:
March 6, 2003
Date of Patent:
March 20, 2007
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
Type:
Grant
Filed:
October 25, 2002
Date of Patent:
August 23, 2005
Assignee:
Darwin Discovery Ltd.
Inventors:
Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
Abstract: Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.
Type:
Grant
Filed:
April 2, 2002
Date of Patent:
April 26, 2005
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild, Fred Ramsdell
Abstract: The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the invention have reduced side-effects, especially with respect to joint pain.
Type:
Grant
Filed:
May 21, 2001
Date of Patent:
November 16, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
John Bird, John Gary Montana, Ruth Elizabeth Wills, Andrew Douglas Baxter, David Alan Owen
Abstract: The invention encompasses novel compounds which are inhibitors of matrix metalloproteinase, ADAM or ADAM-TS enzymes, and which are useful for the treatment of diseases mediated by those enzymes, including degenerative diseases and certain cancers.
Type:
Grant
Filed:
May 15, 2001
Date of Patent:
October 26, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
Duncan Robert Hannah, Hazel Joan Dyke, Andrew Sharpe, Andrew Douglas Baxter
Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&bgr; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.
Type:
Grant
Filed:
September 21, 2000
Date of Patent:
October 12, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
Abstract: Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.
Type:
Grant
Filed:
October 24, 2000
Date of Patent:
September 21, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild, Fred Ramsdell
Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
Type:
Application
Filed:
February 27, 2004
Publication date:
August 12, 2004
Applicant:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
Abstract: The invention relates to hydroxamic and carboxylic acid derivatives. Compounds of the formula:
are disclosed. These compounds are useful for the treatment of diseases mediated by inhibitors of matrix metalloproteinase, ADAM, ADAM-TS enzymes, and/or TNF&agr;-mediated diseases including degenerative diseases and certain cancers.
Type:
Grant
Filed:
September 6, 2002
Date of Patent:
May 11, 2004
Assignee:
Darwin Discovery, Ltd.
Inventors:
Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
Type:
Application
Filed:
March 7, 2002
Publication date:
March 25, 2004
Applicant:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan Paeper, Jeffrey Van Ness, David G. Winkler
Abstract: 4-(4-(-Chlorophenyl)piperazin-1-yl)sulfonylmethyl)-tetrahydor yran-4-carboxylic acid and the corresponding N-hydroxy amide, and derivatives thereof, are useful as therapeutic agents.
Type:
Grant
Filed:
June 25, 2001
Date of Patent:
March 16, 2004
Assignee:
Darwin Discovery, Ltd.
Inventors:
Andrew Douglas Baxter, David Alan Owen, Robert John Watson
Abstract: Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.
Type:
Grant
Filed:
October 25, 2000
Date of Patent:
January 27, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild, Fred Ramsdell
Abstract: Compounds having therapeutic utility are of formula (I)
B—X—(CH2)n—CR2R3—CR4R5—COY (I)
wherein
n=0-1;
X is S(O)0-2;
Y is OR1 or NHOH;
R2 and R4 are independently H or a group (optionally substituted with R10) selected from C1-6 alkyl, C2-6 alkenyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, heterocycloalkyl, C1-6 alkyl-heterocycloalkyl, cycloalkyl and C1-6 alkyl-cycloalkyl; and
R1, R3 and R5 are independently H or C1-6 alkyl,
provided that not more than two of R2, R3, R4 and R5 are H; or
any of CR2R3, CR4R5 and CR2—CR4 is a cycloalkyl or heterocycloalkyl ring optionally substituted with R10 or a group (optionally substituted with R10) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl and C1-6 alkyl-heteroaryl;
B is heterocycloalkyl (optionally substituted by R6 or R7) bonded through carbon to X, or C1-6 alkyl-heterocycloalkyl (optionally substituted with R6 or R7), or a group (substituted with R6) selected from C1-8 alkyl
Type:
Grant
Filed:
February 6, 2001
Date of Patent:
January 20, 2004
Assignee:
Darwin Discovery Ltd.
Inventors:
John Gary Montana, Andrew Douglas Baxter, David Alan Owen, Robert John Watson
Abstract: N-oxides of formula (i)
wherein
R1 is CH3, CH2F, CHF2 or CF3;
R2 is CH3 or CF3;
R3 is F, Cl, Br, CN or CH3; and
R4 is H, F, Cl, Br, CN or CH3;
and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g., for the treatment of inflammatory diseases.
Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
Type:
Application
Filed:
March 6, 2003
Publication date:
September 4, 2003
Applicant:
Darwin Discovery Ltd.
Inventors:
Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
Abstract: A unit dosage and pharmaceutical delivery system for anaesthetizing a human patient prior to major surgery, which comprise between 200 mg and 300 mg of levobupivacaine.
Type:
Grant
Filed:
October 1, 2001
Date of Patent:
February 4, 2003
Assignee:
Darwin Discovery, Ltd.
Inventors:
Laurence E. Mather, Andrew John McGlashan Richards
Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
Type:
Grant
Filed:
May 15, 2001
Date of Patent:
January 14, 2003
Assignee:
Darwin Discovery Ltd.
Inventors:
Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter