Abstract: A method includes the following steps: positioning a patient at a first orientation relative to a radiation source, obtaining a measurement of the patient's breathing, and obtaining a measurement of the patient's cardiac function. The method includes, while the patient is positioned at the first orientation relative to the radiation source, and while obtaining the measurement of the patient's breathing phase, determining, from the measurement of the patient's breathing, a breathing phase of the patient and determining, from the measurement of the patient's cardiac function, a cardiac phase of the patient. The method includes gating the radiation source to expose the patient to radiation based on a determination that the breathing phase of the patient matches a predefined breathing phase and a determination that the cardiac phase of the patient matches a predefined window of the cardiac cycle.

Abstract: A method includes positioning a patient at a first orientation relative to a radiation source. The method further includes using a 3D imaging technique to measure one or more positions of the patient's chest. The method further includes, while using the 3D imaging technique to measure the one or more positions of the patient's chest: generating a model of the patient's chest using the one or more positions of the patient's chest; updating the model of the patient's chest as the patient breathes; and exposing the patient to a dose of radiation using the radiation source, wherein the dose is based on the model of the patient's chest.

Abstract: Systems and methods for positioning a patient during radiological measurements are provided. A biofeedback signal from the patient is received. While receiving the biofeedback signal from the patient and while the patient is positioned at a first position by the fixture, determining whether the biofeedback signal from the patient is indicative of the patient breathing at rest. Further, in accordance with a determination that the biofeedback signal from the patient is not indicative of the patient breathing at rest, articulating the patient using the fixture from the first position to a second position. In accordance with a determination that the biofeedback signal from the patient at the second position is indicative of the patient breathing at rest, obtaining radiological measurements of the patient with the patient positioned at the second position.

Abstract: A method of determining a biophysical model for a lung of a patient from multiple x-ray measurements corresponding to different breathing phases of the lung is provided. The method includes extracting multiple displacement fields of lung tissue from the multiple x-ray measurements corresponding to different breathing phases of the lung. Each displacement field represents movement of the lung tissue from a first breathing phase to a second breathing phase and each breathing phase has a corresponding set of biometric parameters. The method includes calculating one or more biophysical parameters of a biophysical model of the lung using the multiple displacement fields of the lung tissue between different breathing phases of the lung and the corresponding sets of biometric parameters.

Abstract: A system obtains multiple x-ray measurements corresponding to different breathing phases of the lung by determining, based on a volumetric measurement of the patient's breathing, a breathing phase of the patient and gating an x-ray imaging apparatus to produce an x-ray projection of the patient's lung when the breathing phase matched any of a plurality of different breathing phases. The system extracts multiple displacement fields of lung tissue from the multiple x-ray measurements corresponding to different breathing. Each displacement field represents movement of the lung tissue from a first breathing phase to a second breathing phase and each breathing phase has a corresponding set of biometric parameters. The system calculates one or more biophysical parameters of a biophysical model of the lung using the multiple displacement fields of the lung tissue between different breathing phases of the lung and the corresponding sets of biometric parameters.

Abstract: A method of generating a 3D x-ray image cube movie from 2D x-ray images of a patient is provided. The method includes converting first multiple sets of x-ray images of a lung captured at different projection angles into second multiple sets of x-ray images of the lung corresponding to different breathing phases. The method further includes generating a static image cube from each set of the second multiple sets of x-ray images at a respective breathing phase using back projection. The method includes combining the static image cubes corresponding to the different breathing phases of the lung into a 3D x-ray image cube movie through temporal interpolation.