Abstract: A method for enrolling patient candidates in a clinical trial includes generating first prediction data indicating predicted progression of a condition for a first group of patients that participated in a first clinical trial using a predictive model and clinical data associated with the first group of patients; grouping clinical trial data into subsets based on the first prediction data; analyzing each subset of clinical trial data to generate a measure of efficacy of the treatment; establishing screening criteria for a second clinical trial by identifying at least one subset that has a measure of efficacy that is higher than a measure of efficacy of the treatment for the full first group of patients; receiving clinical data of a candidate for the second clinical trial; generating second prediction data for the candidate; and enrolling the candidate in the second clinical trial when the second prediction data satisfies the screening criteria.

Abstract: A method for enrolling patient candidates in a clinical trial includes generating first prediction data indicating predicted progression of a condition for a first group of patients that participated in a first clinical trial using a predictive model and clinical data associated with the first group of patients; grouping clinical trial data into subsets based on the first prediction data; analyzing each subset of clinical trial data to generate a measure of efficacy of the treatment; establishing screening criteria for a second clinical trial by identifying at least one subset that has a measure of efficacy that is higher than a measure of efficacy of the treatment for the full first group of patients; receiving clinical data of a candidate for the second clinical trial; generating second prediction data for the candidate; and enrolling the candidate in the second clinical trial when the second prediction data satisfies the screening criteria.

Abstract: A UAV data processing and management system is provided including an encoder broadcaster and data manager which provides end users with a single interface for searching and sharing any video or imagery source, from any device with no client software required. Data inputs to the resource can include UAV video, photos, traffic cameras, fixed surveillance systems, iOS and Android device pictures, and other data (e.g., texts, emails) and inputs from all forms of social media, such as Twitter, Instagram, Facebook, etc. The cloud based manager is built with collaboration and sharing in mind while at the same time maintaining data privacy, security protection, chain-of-custody control and audit trail maintenance. Analytic tools are integrated accordingly as “plug-ins” or as a store of available app resources which are easily removed, added and customized based on user needs and system requirements and cost constraints.

Abstract: A UAV data processing and management system is provided including an encoder broadcaster and data manager which provides end users with a single interface for searching and sharing any video or imagery source, from any device with no client software required. Data inputs to the resource can include UAV video, photos, traffic cameras, fixed surveillance systems, iOS and Android device pictures, and other data (e.g., texts, emails) and inputs from all forms of social media, such as Twitter, Instagram, Facebook, etc. The cloud based manager is built with collaboration and sharing in mind while at the same time maintaining data privacy, security protection, chain-of-custody control and audit trail maintenance. Analytic tools are integrated accordingly as “plug-ins” or as a store of available app resources which are easily removed, added and customized based on user needs and system requirements and cost constraints.

Abstract: A system and method for querying a database is disclosed. Database tables are represented as nodes in a model. Each node is associated with at least one leaf. The nodes can be interconnected with one another. A model input is received by a server from a client device, the model input including a starting node, one or more leaves, and optionally one or more filters. A query is executed against a database based on the model input. A subsequent query can be generated by selecting a result of the first query. Also disclosed is a technique for cancelling queries.

Abstract: A method for enrolling patient candidates in a clinical trial includes generating first prediction data indicating predicted progression of a condition for a first group of patients that participated in a first clinical trial using a predictive model and clinical data associated with the first group of patients; grouping clinical trial data into subsets based on the first prediction data; analyzing each subset of clinical trial data to generate a measure of efficacy of the treatment; establishing screening criteria for a second clinical trial by identifying at least one subset that has a measure of efficacy that is higher than a measure of efficacy of the treatment for the full first group of patients; receiving clinical data of a candidate for the second clinical trial; generating second prediction data for the candidate; and enrolling the candidate in the second clinical trial when the second prediction data satisfies the screening criteria.

Abstract: In system for analyzing large data sets, document/file format can be discovered by attempting to parse the file using several parsers to generate a schema, assigning a score to each parsing, and selecting a parser based on the assigned scores. Schema element attributes, such as statistical parameters, can be derived and used in identifying schema elements associated with other files. Attributes of identified schema elements can be used to substitute missing data values with values based on such attributes. Data values corresponding schema elements can be selected and highlighted, and schema elements and/or attributes thereof can be highlighted based on selected data values. From a cluster of files, a lineage relationship between file pairs, indicating whether one file is derived from another, can be determined for several files. In reducing/compacting data, utilization of all available reducers can be optimized according to current utilization of one or more reducers.

Abstract: Molecular characterization of disease has become the dominant trend in modern medicine, and it has recently become increasingly important to obtain qPCR, microarray, and next-generation sequencing (NGS) data for both research and clinical applications. Formalin-fixed, paraffin-embedded (“FFPE”) samples have become the standard way of storing clinical biopsies throughout the world. Unfortunately, the poor quality and quantity of nucleic acids obtained from such specimens has posed severe limitations on the types of studies that can be accomplished. Existing methods for retrieval of the biomolecules from their crosslinked matrices are poorly effective and rely on harsh conditions which further damage the biomolecules being extracted. The invention provides compositions and methods for retrieval, analysis and use of biomolecules, including nucleic acids, from such samples.

Abstract: In system for analyzing large data sets, document/file format can be discovered by attempting to parse the file using several parsers to generate a schema, assigning a score to each parsing, and selecting a parser based on the assigned scores. Schema element attributes, such as statistical parameters, can be derived and used in identifying schema elements associated with other files. Attributes of identified schema elements can be used to substitute missing data values with values based on such attributes. Data values corresponding schema elements can be selected and highlighted, and schema elements and/or attributes thereof can be highlighted based on selected data values. From a cluster of files, a lineage relationship between file pairs, indicating whether one file is derived from another, can be determined for several files. In reducing/compacting data, utilization of all available reducers can be optimized according to current utilization of one or more reducers.

Abstract: In system for analyzing large data sets, document/file format can be discovered by attempting to parse the file using several parsers to generate a schema, assigning a score to each parsing, and selecting a parser based on the assigned scores. Schema element attributes, such as statistical parameters, can be derived and used in identifying schema elements associated with other files. Attributes of identified schema elements can be used to substitute missing data values with values based on such attributes. Data values corresponding schema elements can be selected and highlighted, and schema elements and/or attributes thereof can be highlighted based on selected data values. From a cluster of files, a lineage relationship between file pairs, indicating whether one file is derived from another, can be determined for several files. In reducing/compacting data, utilization of all available reducers can be optimized according to current utilization of one or more reducers.

Abstract: Systems and methods for querying a database are disclosed. A server computing device includes a processor and a memory storing instructions that, when executed by the processor, cause the server computing device to: receive a query input from a client device over a network connection; establish a non-blocking socket between the client computing device and the server computing device; generate a database query based on the query input; cause the database query to begin executing against one or more databases; perform a read request on the non-blocking socket; receive a code in response to the read request on the non-blocking socket; determine whether the network connection exists between the client device and the server device based on the received code; and cause the database query to be cancelled when the server determines that the network connection does not exist between the client device and the server device.

Abstract: The present disclosure provides methods for performing a computation with an aggregate function using a database query, wherein the database query joins a plurality of database tables and includes a distinct aggregation function, which, when executed against one or more databases aggregates only values of database records corresponding to distinct keys by which the tables are joined, regardless of the cardinality of the joined tables. Related devices and systems are also provided.

Abstract: The present disclosure provides inclusive and exclusive approaches, including computer-implemented methods for selectively retrieving data from an initial dataset in a relational database to provide a limited dataset for incorporation into a pivot table. Also provided are related systems and non-transitory computer-readable recording media.

Abstract: A system and method for querying a database is disclosed. Database tables are represented as nodes in a model. Each node is associated with at least one leaf. The nodes can be interconnected with one another. A model input is received by a server from a client device, the model input including a starting node, one or more leaves, and optionally one or more filters. A query is executed against a database based on the model input. A subsequent query can be generated by selecting a result of the first query. Also disclosed is a technique for cancelling queries.

Abstract: Methods and apparatus for a system that solicits suggestions and evaluations of options (for goods, services, business/personal relationships, decisions, etc.) tailored to a subject. The evaluators, which may include the subject, provide input on the options (a rating, ratings, written evaluation, etc.) with respect to the subject. After receiving one or more such evaluations, the system may formulate a recommendation for the subject. If so, the system may notify the subject, evaluators, and/or other parties. It may also take appropriate actions to facilitate the recommendation (i.e., make a product available for sale, email a coupon, pass along a résumé, exchange contact information, etc.).

Abstract: A system and method for querying a database is disclosed. Database tables are represented as nodes in a model. Each node is associated with at least one leaf. The nodes can be interconnected with one another. A model input is received by a server from a client device, the model input including a starting node, one or more leaves, and optionally one or more filters. A query is executed against a database based on the model input. A subsequent query can be generated by selecting a result of the first query. Also disclosed is a technique for cancelling queries.

Abstract: Systems and methods for querying a database are disclosed. A server computing device includes a processor and a memory storing instructions that, when executed by the processor, cause the server computing device to: receive a query input from a client device over a network connection; establish a non-blocking socket between the client computing device and the server computing device; generate a database query based on the query input; cause the database query to begin executing against one or more databases; perform a read request on the non-blocking socket; receive a code in response to the read request on the non-blocking socket; determine whether the network connection exists between the client device and the server device based on the received code; and cause the database query to be cancelled when the server determines that the network connection does not exist between the client device and the server device.

Abstract: Measurement of a physiological pressure is accomplished by placement of a pressure transmitting catheter within a blood vessel or other structure within which pressure is to be measured. The catheter is blood-compatible, capable of withstanding handling during distribution and implantation, and provides adequate pressure transmission frequency response in a variety of applications. The catheter, which includes a hollow flexible tube filled with a low viscosity fluid and having a plug of a gel-like material at its distal end, transmits the pressure signal to a solid-state transducer which is typically connected to amplifying electronics and an implantable radio-transmitter capable of relaying the pressure information from within the body to a radio receiver located external to the body.

Abstract: A device capable of sensing pressure allows the sensor and amplifying electronics to be packaged in a very small size and implanted within the body. The sensor consists of a small catheter, the tip of which is placed at the point at which pressure is to be measured, attached to a solid-state pressure sensor. The catheter is filled with a fluid and is connected to an implantable infusion pump which dispenses through the lumen of the catheter, heparin or other drug which inhibits thrombogenisis.

Abstract: A telemetry system includes a transmitter, which is either placed in the vagina or is implanted in the vulvular or vaginal tissue, and a receiver. The transmitter is capable of measuring physiological parameters which are indicative or predictive of the occurrence of estrus. These parameters may include but are not limited to tissue impedance, temperature and activity of the animal. This provides a pulsed method of measuring impedance of vulvular or vaginal tissue which enhances the marketability of such a device by reducing its size, weight and complexity without sacrificing accuracy or reliability. Data telemetered from this device is preferably collected by a computer and automatically analyzed to provide a report to the farm manager as to which animals are in estrus or are expected to be in estrus at a given time.