Abstract: A thoracic drainage system for removing liquid from the thoracic cavity of a patient. The system includes a reusable thoracic vacuum regulator and a standard disposable collection container. A disposable water seal chamber is also provided that can be disposed of after each patient and is a separable, independent component. There is also a combination thoracic vacuum regulator having a water seal chamber removable affixed thereto to enable the water seal chamber to be readily removed from the thoracic vacuum chamber in order to carry the water seal chamber along with the patient as that patient is transported.