Abstract: An artificial tissue construct for nerve repair and regeneration includes a biocompatible and biodegradable nerve guidance matrix comprising a plurality of biopolymers that include chitosan, gelatin, collagen and hyaluronic acid. A cross-linker includes glutaraldehyde. The nerve guidance matrix is formed as a three-dimensional scaffold polyelectrolyte complex (PEC). A subconfluent and grown monolayer of at least one of human mesenchymal stem cells, mesenchymal stem cells, differentiated Schwann cells and neuronal cells is on the biocompatible and biodegradable nerve guidance matrix for direct implantation or delivery. A method of making the artificial tissue construct is disclosed.
Abstract: This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
Type:
Grant
Filed:
June 8, 2021
Date of Patent:
March 28, 2023
Assignee:
DATT LIFE SCIENCES PRIVATE LIMITED
Inventors:
Rajan Datt, Siddharth Pandey, Pallavi Shrivastava, Ramadhar Kumar
Abstract: This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phytopharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
Type:
Grant
Filed:
October 10, 2019
Date of Patent:
July 13, 2021
Assignee:
DATT LIFE SCIENCES PRIVATE LIMITED
Inventors:
Rajan Datt, Siddharth Pandey, Pallavi Shrivastava, Ramadhar Kumar
Abstract: A method is for making a hemostat device. The method includes preparing a homogenous solution of gelatin and chitosan by adding gelatin to water to form a gelatin solution, adding an acid to the gelatin solution to provide an acidified gelatin solution, and adding chitosan to the acidified gelatin solution to form the homogenous solution of gelatin and chitosan. The method also may include air drying the homogenous solution of gelatin and chitosan to provide an air dried scaffold, processing the air dried scaffold to provide a porous sponge, loading the porous sponge with a clotting agent by exposing the porous sponge to the clotting agent in an aqueous solution, and drying the loaded porous sponge.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
May 19, 2020
Assignee:
Datt Life Sciences Private Limited
Inventors:
Rajan Datt, Ramadhar Kumar, Pallavi Shrivastava
Abstract: This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
Type:
Grant
Filed:
August 29, 2018
Date of Patent:
February 18, 2020
Assignee:
DATT LIFE SCIENCES PRIVATE LIMITED
Inventors:
Rajan Datt, Siddharth Pandey, Pallavi Shrivastava, Ramadhar Kumar
Abstract: The invention relates to porous absorbent Composite Material, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides a hydrophilic Self-Dispersive, fragmentable and Bio-Absorbable Porous Composite foams, suitable for packing antrum or other cavities of the body, comprising of composite of polymers, which polymer preferably comprises —C(O)—O—; NH2/3+; —OH; —CH2OCH2C(O)O— groups as functional or —CH—O— (e.g. C2H4O; C6H10O5; C6H8O6); —CH—N—O— (e.g. C8H13NO5); O—C—C— (e.g. O—CH2-CH2); —C(O)N— groups in the backbone of the polymers e.g. gelatin, chitosan, collagen, alginate, polyvinyl alcohol, polyethylene glycol, keratin, cellulose.
Type:
Grant
Filed:
March 25, 2016
Date of Patent:
May 21, 2019
Assignee:
DATT LIFE SCIENCES PRIVATE LIMITED
Inventors:
Rajan Datt, Ramadhar Kumar, Siddharth Pandey, Pallavi Shrivastava
Abstract: The invention provides a ready to use biodegradable and biocompatible device and a method for manufacturing thereof. The device of present invention is a novel porous scaffold which can be used as carrier of plurality of therapeutics to quickly stop bleeding and other biomaterial and biomedical application. The scaffold can be directly applied to the spot of the wound and will stop bleeding within no time. The scaffold of the present invention comprises of combined application of air dry and freeze dry method. The scaffold also comprises of excellent ventilations properties and easy removal of the scaffold without causing any extra hemorrhage to the wound.
Type:
Grant
Filed:
August 21, 2014
Date of Patent:
November 13, 2018
Assignee:
Datt Life Sciences Private Limited
Inventors:
Rajan Datt, Ramadhar Kumar, Pallavi Shrivastava