Abstract: The present disclosure is directed to cross-flow membrane emulsification devices. The devices disclosed herein can have a continuous phase plate, a dispersed phase plate, an outlet, and a chamber. The chamber is located between the continuous phase plate and the dispersed phase plate and is bisected by a membrane with a plurality of pores. The chamber can include at least one channel on a first side of the membrane formed from at least one groove in the continuous phase plate and the membrane. In addition, the chamber can also include a cavity on a second side of the membrane formed in the dispersed phase plate.

Abstract: Provided herein are microspheres (e.g., single emulsion microspheres) comprising a therapeutic compound or pharmaceutically acceptable salt thereof, one or more polymers, and optionally a polyol, as well as methods of preparation, methods of use, and pharmaceutical compositions related thereto.