Abstract: A method and system is provided for the growth of the molluscum contagiosum virus in human skin xenografted to an immunocompromised host. A human skin graft is infected with molluscum contagiosum virus attached to or beneath a skin section of the immunocompromised host. According to the method, a section of skin of an immunocompromised host is prepared for receiving a human skin xenograft which is then placed onto or into the host. The human skin is infected with the molluscum contagiosum virus. The animals are monitored and the newly grown virus and its products are harvested for further study.