Patents Assigned to David M. Neville, Jr.
  • Thymus tolerance in primates
    Patent number: 5762927
    Abstract: Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: June 9, 1998
    Assignees: Wisconsin Alumni Research Foundation, David M. Neville, Jr.
    Inventors: Stuart J. Knechtle, Jue Wang, Jon A. Wolff, David M. Neville, Jr.