Abstract: A hernia repair device, comprising: an inflatable balloon having an inflation tube, the inflation tube having a proximal end attached to said balloon and a distal end adapted to be extracted from the body, separately from the balloon, via an opening which is smaller than a laparoscopic opening; and a mesh removably attached to said balloon, wherein the inflation tube passes through the mesh.

Abstract: Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.

Abstract: Embodiments disclosed herein relate to prosthetics for augmenting or repairing a tissue defect, such as a ventral or incisional hernia. In some embodiments, a repair prosthetic may include a patch body and a first fastener attached to a first portion of the patch body. A coupler may be attached to and extend from a second portion of the patch body, and a second fastener may be attached to the second portion of the patch body via the coupler. The coupler may be retracted relative to the second portion of the patch body or the second fastener to apply tension to the patch body in some embodiments.

Abstract: An elongate open-bored applicator (EOBP) adapted to deploy a mesh comprising (a) at least one inflatable contour-balloon, (b) at least one inflatable dissection balloon. The inflatable contour-balloon and the inflatable dissection balloon are adjustable and located at the distal portion; and, (c) at least one actuating means located at the proximal portion. The actuating means is in communication with the inflatable contour-balloon and the inflatable dissection balloon. The actuating means is adapted to provide the inflatable contour-balloon and the inflatable dissection balloon with independent activation and/or de-activation.

Abstract: Compositions and methods related to flowable hemostats that crosslink during and/or after application to a bleeding site are generally described.

Abstract: An implantable prosthesis including a tissue infiltratable body of biocompatible material, the prosthesis having a body with a three-dimensional configuration to augment and/or reconstruct an anatomical shape of a human breast. The body includes a plurality of body segments stacked on top of one another about a longitudinal axis extending in a direction from a proximal end to a distal end of the prosthesis. The proximal end is configured to be positioned against facia in an anatomical space.

Abstract: Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.

Abstract: An implantable prosthesis for repairing a defect in a muscle or tissue wall. The prosthesis comprises a body of biologically compatible prosthetic material having a preformed three-dimensional contoured shape that independently assumes a three-dimensional curved shape configured to conform to the muscle or tissue wall. The body may be formed of a mesh fabric employing a knit construction. The body may be configured with one or more mechanical characteristics, individually or in any combination, having defined properties which may enhance the ability of the prosthesis to be handled in a surgical, robotic environment while meeting the performance and physical characteristics for soft tissue repair and reconstruction. One or more visual indicia may be provided to facilitate positioning and/or placement of the prosthesis at the muscle or tissue wall.

Abstract: A prosthesis for reconstruction and/or augmentation of an anatomical shape. The prosthesis may have a three-dimensional configuration to reconstruct and/or augment the anatomical shape of a human breast. The prosthesis may be configured to encourage ingrowth of fat and/or tissue to fill open spaces within and about the prosthesis. The prosthesis may employ a structure having a plurality of cavities to allow fat and/or tissue to fill and pass through the structure and fill-out the anatomical shape of the reconstructed and/or augmented breast. The prosthesis may include a hollow core which may be accessible from one or both ends of the prosthesis. The prosthesis may be fabricated using a plurality of segments and/or layers of material which can be arranged about the core and joined to create the desired shape for the prosthesis.

Abstract: An implantable prosthesis having a tissue infiltratable body of biocompatible material includes a plurality of body components arranged radially or circumferentially about a longitudinal axis of the body extending from a proximal end to a distal end of the body. The longitudinal axis may define a central axis of the prosthesis. Each body component includes an outer layer defining a cavity. The outer layer may be substantially conically shaped and/or pleated. A filler may be disposed within the cavity. The body may be attached to abase. The body is configured to augment and/or reconstruct an anatomical shape of a human breast.

Abstract: Embodiments related to surgical anchors are described. In some embodiments, a surgical anchor may include a selectively removable blocker which may prevent one or more barbs of the surgical anchor from engaging with adjacent tissue until the selectively removable blocker is removed.

Abstract: Surgical instruments and their methods of use are disclosed. In some embodiments, the surgical instrument may include a handle and an elongated shaft extending distally from the handle. The surgical instrument may also include a fastener deployment system for deploying fasteners from the elongated shaft including a reciprocating driveshaft disposed within the elongated shaft. In other embodiments, the fastener deployment system may include a follower disposed within the elongated shaft for displacing one or more fasteners within the elongated shaft towards a distal fastener deployment position. In some embodiments, the surgical instrument may include a magnetic preload lock-out to place the follower in a zero-load state in which the follower does not apply a preload to the fasteners.

Abstract: Surgical devices and related methods for use with sutures are generally described. In some embodiments, a surgical device may include an elongated body and a plurality of through holes configured to allow a suture to pass through the plate across opposing edges of a defect site. The plate may shield neighboring tissue from tension in the suture line by re¬distributing the tension along its body. In some embodiments, the disclosed surgical devices may reduce the likelihood of defect closure failure caused by the suture pulling through a tissue defect. In some embodiments, the through holes may be located on offset parallel axes to reduce excessive suture friction and suture mismanagement. The disclosed surgical devices may be used with either interrupted or continuous suture patterns.

Abstract: Devices and methods for closure of apertures in tissue (e.g., defects in fascial tissue) are generally provided. Closure of apertures in tissue, e.g., using sutures and patch closures, are common surgical operations. In some aspects, methods and devices for using tissue grippers to engage tissue portions, and subsequently biasing the tissue grippers and tissue portions towards one another by changing a configuration of a lock are generally provided. In other aspects, methods and devices for measuring a retraction force applied by tissue grippers to tissue portions are generally provided.

Abstract: A tissue aperture closure device may include more than one suture deployed in multiple directions around a perimeter of a tissue aperture. The sutures may be pulled through a suture lock to tension the sutures and close the tissue aperture. The suture lock may be transitioned between a locked configuration and an unlocked configuration in which the tension of the sutures may be adjusted.

Abstract: Vibrational powder applicators and related methods are disclosed. In some embodiments, a vibrational powder applicator may include a powder storage chamber, a powder (e.g., a therapeutic powder) disposed within the powder storage chamber, an actuator operatively coupled to the powder storage chamber and configured to vibrationally agitate the powder when activated, and an outlet in fluid communication with the powder storage chamber. In some embodiments, a vibrational powder applicator may include a flow restrictor and/or a valve.

Abstract: Embodiments related to surgical anchors are described. In some embodiments, a surgical anchor may include a selectively removable blocker which may prevent one or more barbs of the surgical anchor from engaging with adjacent tissue until the selectively removable blocker is removed.

Abstract: The present invention provides a fixating means adapted for use in hernia repair surgeries in attaching a mesh and mesh deployment means; said fixating means are attached to said mesh deployment means; and fixating means comprising: (a) a first portion coupled to said deployment means; and, (b) a second portion comprising a coil having a predetermined retracted shape; said coil is reconfigurable from a plurality of unretracted positions to a plurality of retracted positions and from said plurality of retracted positions to said plurality of unretracted positions; wherein said attachment between said deployment means and said mesh is obtained by reconfiguration of said coil from at least one of said unretracted positions to at least one of said retracted positions.

Abstract: Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are generally described.

Abstract: The present invention provides a fixating means adapted for use in hernia repair surgeries in attaching a mesh and mesh deployment means; said fixating means are attached to said mesh deployment means; and fixating means comprising: (a) a first portion coupled to said deployment means; and, (b) a second portion comprising a coil having a predetermined retracted shape; said coil is reconfigurable from a plurality of unretracted positions to a plurality of retracted positions and from said plurality of retracted positions to said plurality of unretracted positions; wherein said attachment between said deployment means and said mesh is obtained by reconfiguration of said coil from at least one of said unretracted positions to at least one of said retracted positions.