Abstract: A medical tube holder for attachment to a patient's nose septum for holding medical tubing inserted into the patient's nose. The tube holder includes opposite upstanding clamp arms defining an acute included angle therebetween for insertion into the nostril and thereby into clamp engagement on opposite sides of the patient's septum. One of the nasal clamp arms includes a tube holder section for substantially surrounding and maintaining medical tubing in position. A thumbscrew adjusts the distance between the upstanding clamp arms and therefore the clamping pressure on the septum. A rotating screw in another embodiment is fixed to one clamp arm and threadably mounted on another clamp arm to provide threadable adjustment. A locking pin and detent configuration in a further embodiment enables adjustment of the clamp arms between preset positions. An integral unit in a still further embodiment with two opposing upstanding clamp arms set at an optimum acute included angle therebetween.