Patents Assigned to DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS MINISTERIE VAN VOLKSGEZONDHEID, WELZUN EN SPORT
  • Process for detergent-free production of outer membrane vesicles of a gram-negative bacterium
    Patent number: 9707286
    Abstract: The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: July 18, 2017
    Assignee: DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS MINISTERIE VAN VOLKSGEZONDHEID, WELZUN EN SPORT
    Inventors: Bas Van De Waterbeemd, Leonardus Aldolfus Van Der Pol