Patents Assigned to De Staat Der Nederlanden
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Patent number: 4900549Abstract: The invention relates to a process for preparing immunogenic complexes in which an amphiphatic antigenic protein or peptide in dissolved or solubilized form is contacted with a solution containing a detergent, a sterol, and a glycoside comprising hydrophobic and hydrophilic regions, in at least the critical micelle forming concentration, the detergent is removed, and the immunogenic complex formed is purified. Optionally, the solution with which the antigenic protein or peptide is contacted also contains a phospholipid, preferably phosphatidylethanolamine. The preferred sterol is cholesterol, and preferred glycosides are saponins, espeically Quil A.The immunogenic complex is useful as a vaccine. Its immunogenic power is higher than that of corresponding micelles formed by aggregation of the antigens, and is also higher than that of the antigens incorporated in liposomes.Type: GrantFiled: January 14, 1987Date of Patent: February 13, 1990Assignee: De Staat der Nederlanden Vertegenwoordigd door de Minister van Welzion, Volksgezondheid en CultuurInventors: Petra De Vries, Antonius L. van Wezel, deceased, Eduard C. Beuvery
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Patent number: 4508708Abstract: The invention relates to virus vaccines and to a process for the preparation thereof especially to polio virus vaccines and other picorna virus vaccines, such as foot-and-mouth disease vaccine.The invention provides vaccines which are stabilized and show an improved activity by the addition of compounds of formula I of the formula sheet, in which R.sub.1 en R.sub.2 each represent an alkyl- or alkoxy group of not more than 6 carbon atoms, preferably not more than 4 carbon atoms,A represents a bivalent hydrocarbon radical of 3-12 carbon atoms,R.sub.3 represents an unsubstituted or substituted phenyl radical and n is 1 or 0.Type: GrantFiled: June 2, 1982Date of Patent: April 2, 1985Assignee: De Staat Der Nederlanden, Vertegenwoozdigd doozde Minister van volksgezondheid en MilieuhygieneInventor: Antonius L. Van Wezel
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Patent number: 4257673Abstract: The invention provides a coupling device for monochromatic optical signals based on the amplitude division method. The optical signal emerging from one light guide is divided by means of one or more diffraction gratings among three or more outgoing light guides. Inversely, the optical signals from a number of light guides can be combined into one optical signal. Such a coupling device has a high optical efficiency, is mode-independent and produces small differences in light intensity between the branch signals.Type: GrantFiled: December 18, 1978Date of Patent: March 24, 1981Assignee: De Staat der Nederlanden, Te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegraphie en TelefonieInventor: Pieter Matthijsse
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Patent number: 4247857Abstract: Method for controlling an antenna of an earth station for telecommunication via satellites, which antenna is provided with means to determine the position of the antenna and with means to ascertain the strength of the received signal, the direction of each change of position to be made by the antenna being derived from the change of the signal strength and the attendant change of position in consequence of the uncontrolled changes of position made by the antenna with respect to the position chosen.Type: GrantFiled: August 21, 1978Date of Patent: January 27, 1981Assignee: De Staat der Nederlanden, te dezen vertegenwoordigd door de directeur-generaal der Posterijen, Telegrafie en TelefonieInventors: Robert Wilcke, Antoon A. J. Otten
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Patent number: 4213602Abstract: Belt type conveyors for letters and the like, having a switching device between them, which device comprises a roller having a flattening on its circumference i.e. a segmented roller, driven by means of a one-rotation coupling when a letter is sensed on the conveyor approaching the switching device.Type: GrantFiled: June 9, 1978Date of Patent: July 22, 1980Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Cornelis Kuijt
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Patent number: 4214124Abstract: Method and device for extracting a synchronizing signal from a digital signal. The synchronizing signal can be a single bit, a word or a subframe. A first circuit searches for the synchronizing signal in a fixed position in the received signal every time it should occur. If this circuit does not find the synchronizing signal when it should, a second circuit starts a search action for it in the received signal. When the first circuit has not found the synchronizing signal a fixed number of times, the loss of synchronism will be signalled to the equipment that follows. If in the mean time the second circuit has found the synchronizing signal a fixed number of times in the same position in the received signal, then the first circuit will be synchronized with the second circuit. This synchronism only occurs if the second circuit has found the synchronizing signal a greater number of consecutive times than the first circuit within the same period of time.Type: GrantFiled: September 25, 1978Date of Patent: July 22, 1980Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Daniel J. Jarus
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Patent number: 4205345Abstract: Method and device for eliminating the background brightness variation of a video signal, in which the background brightness in each line of the frame of a video signal has its low frequency brightness signal a(t) limited, as well as being limited by its deviation from the limited brightness of the preceding line of frame. This can be expressed mathematically by stating that .vertline.V(t)-a(t).vertline. is minimized by means of a(t) on the marginal conditions.vertline.a(t)-a(t-T).vertline..ltoreq..epsilon. and.vertline.a(t)-a(t-.DELTA.).vertline..ltoreq..epsilon.,in whichV(t)=the video signal V at the moment t;a(t)=an estimation of the background brightness variation a(t);T=the duration of a line;.DELTA.=h/b T/k, in which h/b=the height/width ratio of the image and k=the number of lines per frame, and.epsilon.=the maximum value of the derivative of a(t) multiplied by .DELTA..Type: GrantFiled: May 22, 1978Date of Patent: May 27, 1980Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Derk van der Houwen, Robert Wilcke
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Patent number: 4180843Abstract: Device for protecting electric systems, particularly telecommunication systems, against overvoltage, comprising the combination of a tube of conducting material and permitting a passage through the wall with an overvoltage protective circuit placed in the tube and comprising at least two diverting components, in such a way that a voltage peak, even with a steepness of 5kV/nsec, can be diverted step by step.Type: GrantFiled: December 22, 1977Date of Patent: December 25, 1979Assignee: De Staat der Nederlanden, te dezen vertegenwoordigd door de directeur-generaal der Posterijen, Telegrafie en TelefonieInventors: Rijnder Hagedoorn, Ernest J. E. Koenderink
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Patent number: 4163122Abstract: A method and apparatus for automatically correcting errors in the cyclic routing memory of a four-wire TDM telecommunication exchange. The address data in the cyclic routing memory for the control of each of the two switching paths for one four-wire connection through the exchange are each stored in a separate column of the cyclic routing memory. The address data includes parity bits for the input buffer storage device, and parity and busy bits for the switching matrix and group switch devices. The cyclic routing memory also include a common clock means for synchronizing all of the memory circuits with a given time period for a test word for checking synchronization of all of the memories in the exchange. Thus, if the data for the control of one of the switching paths should be lost due to a fault, these data can be derived from the data for the control of the other switching path of the same connection.Type: GrantFiled: February 21, 1978Date of Patent: July 31, 1979Assignee: De Staat der Nederlanden, Te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefinieInventor: Barend L. de Goede
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Patent number: 4160902Abstract: Optical reading head, particularly for reading luminescent code bars on documents and the like, which reading head is provided with a source of light for irradiating the bars, with a detector including a hollow optical guide means for collecting the rays emitted by the bars, said guide means being made of a filter material transmitting ultraviolet radiation at least at the end of said guide near the point where the rays are collected.Type: GrantFiled: December 14, 1977Date of Patent: July 10, 1979Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Hans van Wijngaarden
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Patent number: 4127833Abstract: Filter chain comprising at least two cascaded duals, each provided with two acoustically coupled resonators, only one of the two resonant frequencies of each of the duals falling within the filter pass band; the duals are convex at least on one side so as to render the acoustic coupling between the resonators so strong that the distance between the two resonant frequencies of the dual is as great as possible.Type: GrantFiled: January 31, 1977Date of Patent: November 28, 1978Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Jan A. Bezemer, Herman R. C. Tromp
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Patent number: 4117315Abstract: Calculating device provided with scales for calculating radioactive doses and intensities, in which the scales are arranged for calculating the product of the intensity in a radioactive area at a given instant and a dose factor to be determined by experiment. This dose factor depends on the moment when the contaminated area is entered and on the time spent in the area.Type: GrantFiled: February 7, 1977Date of Patent: September 26, 1978Assignee: De Staat der Nederlanden, Te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Cornelis Georg Frederik Ampt, Keimpe Klaas Keimpema
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Patent number: 4109856Abstract: Method and device for transmitting binary signals by means of digital self-synchronizing scramblers, the information of the storage elements used being utilized, in combination with that of the input signal, for detecting the degenerative condition of a long series of identical bits.If the said condition is still existing after a number of consecutive clock periods, a change is made in it by inverting one bit of the input signal.The detection and the inversion also take place at the receiving end, thus ensuring an unerring working of the system.Type: GrantFiled: May 10, 1976Date of Patent: August 29, 1978Assignee: De Staat der Nederlanden, Te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Marius van Beveren, Peerke Jan Nuhoff
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Patent number: 4092630Abstract: A system for reducing the time for repeating erroneous signals through a series of interconnected ARQ-circuits (automatic error correction circuits), in which the durations of the repetition cycles of the ARQ-circuits, as compared to one another, are not equal. The system comprises means at a connection point and capable of storing a number of signals related to each propagation time of a circuit located before the connection point, when a circuit located behind the connection point goes through a repetition procedure including means for generating a special signal to indicate when a repetition procedure is in process in one of said ARQ interconnected circuits to prevent the other interconnected ARQ circuits from also going through their repetition procedures.Type: GrantFiled: October 15, 1976Date of Patent: May 30, 1978Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Hendrik Cornelis Anthony VAN Duuren, Herman DA Silva
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Patent number: 4091235Abstract: A printer, comprising a printing element which, when in operating position, is placed in a magnetic field, and is connected to a secondary winding of a transformer. This transformer has two additional secondary windings and two primary windings which are connected to a circuit so arranged that after a start pulse, two current pulses of opposite directions are successively supplied to the transformer of which only the second pulse effects movement of the printing element. The two primary windings are each connected to an amplifier, each of which supplies one of the current pulses. The input of the circuit and the amplifiers are coupled in such a way that the start pulse controls one of the amplifiers which in turn, through the two additional secondary windings and a blocking circuit, controls the other amplifier to produce the second pulse.Type: GrantFiled: March 31, 1977Date of Patent: May 23, 1978Assignee: De Staat Der Nederlanden, Te Dezen Vertegenwoordigd Door De Directeur-Generaal Der Posterijen, Telegrafie En TelefonieInventor: Emil Johan Nijenhuis
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Patent number: 4068309Abstract: Method for detecting, in a combined digital signal, the presence of two signals differing in frequency, amplitude and phase and having frequencies occurring in a known series. Samples of the combined signal are multiplied by samples of only one derivative of each of the frequencies of the known series. This derivative is formed by the product of a modulating factor formed by the samples of a frequency which is the sum or the difference of (a) a fixed frequency of 2000 Hz and the frequency to be detected in the known series and (b) a factor allowing a filtering at the said fixed frequency and formed by the samples of the sine of the fixed frequency shifted by 45.degree.. These products are alternately stored in accumulators until after a certain time the presence of certain frequencies is deduced from the sum of the products in the accumulators by means of comparison.Type: GrantFiled: November 15, 1976Date of Patent: January 10, 1978Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Chaim Zalman Drukarch
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Patent number: 4066999Abstract: Method and device for recognizing characters, in which in a learning phase, as well as in a subsequent working phase features of character patterns in a number of aspects thereof are classified in a number of groups. During the learning phase the results of these classifications are recorded in a store as statistic frequencies. During the working phase the result of the feature classification of a freshly offered character is utilized in determining, for each class of characters, (a) the probabilities of the features found in this character, and (b) the weight of the features of a character pattern to be recognized. The weight attributed to each feature depends upon the shape of the pattern, and upon the basis of the values of these weights, the features are selected. The stored statistic frequencies of the selected features are multiplied by the values of the weights, and the largest value among the results is utilized for indicating the class of the feature.Type: GrantFiled: May 28, 1976Date of Patent: January 3, 1978Assignee: De Staat der Nederlanden, to Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Arie Adriaan Spanjersberg
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Patent number: 4056781Abstract: A ground station system for automatically monitoring a predetermined plurality of carrier frequencies for radio communication calls from aircraft which transmit and receive traffic over one of said carrier frequencies, wherein the aircraft transmits a calling code signal for a selected ground station, and each of the ground stations has a separate receiver for each of said carrier frequencies. Each receiver is connected to a decoding device which detects only complete and correct calling code signals for that particular ground station. In addition to each of the calling code signals having a first calling part for the pre-selected ground station, each calling code signal also may have a second or an information part indicating the direction sector of the aircraft with respect to the called ground station, the way of modulation or modulation scheme, e.g. A-M or S.S.B., and the company or party being called at that station.Type: GrantFiled: September 20, 1976Date of Patent: November 1, 1977Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Albert Hetebrij, Cornelis Adrianus Geertrudis Kloeck
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Patent number: 4029957Abstract: Detection device for detecting movements by means of a source of light and a photo-detector, which device is provided with: (1) a pulse generator for supplying the source of light with a proportionally very large amount of energy during a very small part of the time; and (2) with a comparator, synchronized with the pulse generator, for comparing a signal received from the photo-detector with the preceding signal during the said time and for delivering a signal to a counter in case a difference is ascertained. The device can be utilized in a manual sorting device comprising one or more sorting-cases. Movements of the upper surface of the stack in a pigeon-hole can be detected by means of reflection. The detection devices in the pigeon-holes are connected via multiplexers and demultiplexers to a central processing unit that has been provided.Type: GrantFiled: October 8, 1975Date of Patent: June 14, 1977Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventors: Frans Betz, Jacobus Johannes DE Haas, Petrus Cornelis VAN DER Kraan
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Patent number: 4014027Abstract: Omnidirectional antenna provided with a rotation-symmetrical reflector and a concentric radiator, to be mounted around a mast, which radiator has an uninterrupted annular exit edge. All the diametrical cross sections of the radiator along the axis of the antenna are uniform. The path followed by the radiation in the radiator beyond the part deflecting from the axis of the antenna, is turned up in the direction of the reflector.Type: GrantFiled: January 19, 1976Date of Patent: March 22, 1977Assignee: De Staat der Nederlanden, te Dezen Vertegenwoordigd Door de Directeur-Generaal der Posterijen, Telegrafie en TelefonieInventor: Michiel Antonius Reinders