Abstract: The present invention extends to methods, systems, for malware end-point prevention to refrain malware components from being executed, by detecting execution of sequence of programmed instructions within a computer-based environment; subsequently, automatically suspending all execution of the sequence of the programmed instructions within the computer-based environment; injecting a new remote thread into the sequence of the programmed instructions; and executing the injected remote thread as an isolated particle while the execution of the sequence of the programmed instructions within the computer-based environment is still suspended, wherein the injected remote thread is configured to intercept function calls of application program interface (API) within the programmed instructions and dynamically modify the executable.