Abstract: Systems and methods are provided for screening histopathology tissue samples. An anomaly detection system is trained on a plurality of training images. Each of the plurality of training images represents a tissue sample that is substantially free of abnormalities. A test image, representing a tissue sample, is provided to the anomaly detection system. A deviation from normal score is generated for at least a portion of the test image. The deviation from normal score represents a degree of abnormality in the tissue sample represented by the test image.