Patents Assigned to Declion Holdings LLC
  • Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
    Patent number: 9533037
    Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: January 3, 2017
    Assignee: Declion Holdings LLC
    Inventors: Dustan Bonnin, Eric Zanelli, Jeff Krieger, Thomas Mathers