Patents Assigned to Declion Pharmaceuticals, Inc.
  • DIRECTED SEQUENCE POLYMER COMPOSITIONS AND ANTIBODIES THEREOF FOR THE TREATMENT OF PROTEIN CONFORMATIONAL DISORDERS
    Publication number: 20140271614
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 18, 2014
    Applicant: DECLION PHARMACEUTICALS, INC.
    Inventors: Dustan Bonnin, Eric Zanelli, Thomas P. Mathers
  • Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    Patent number: 8546532
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: October 1, 2013
    Assignee: Declion Pharmaceuticals, Inc.
    Inventors: Dustan Bonnin, Eric Zanelli, Thomas Mathers
  • METHODS FOR DESIGNING AND SYNTHESIZING DIRECTED SEQUENCE POLYMER COMPOSITIONS VIA THE DIRECTED EXPANSION OF EPITOPE PERMEABILITY
    Publication number: 20130115233
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino add of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 9, 2013
    Applicant: Declion Pharmaceuticals, Inc.
    Inventor: Dustan Bonnin
  • Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
    Patent number: 8378072
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: February 19, 2013
    Assignee: Declion Pharmaceuticals, Inc.
    Inventor: Dustan Bonnin