Abstract: A device (2) for supporting and positioning a microscope, the device comprising a support suitable for being tied to a fixed frame of reference, and a plate suitable for supporting a microscope (17), an intermediate moving element (7) being connected firstly to said support (2) via a first series of motor-driven hinged members (6) of parallel type structure having three Cartesian XYZ degrees of freedom and to said plate via a second series of motor-driven members (9) gimbal-type structure providing three degrees of freedom in rotation, the device including control means generating control signals that are used by a computer for servo-controlling the displacement of the microscope (17).