Abstract: The present disclosure provides a method for determining a malignancy likelihood score for breast tissue of a patient. The method includes receiving a plurality of two-dimensional images of the breast tissue, the two-dimensional images being derived from a three-dimensional image of the breast tissue, for each two-dimensional image, providing the two-dimensional image to a first model including a first trained neural network, and receiving a number of indicators from the first model, each indicator being associated with a two-dimensional image included in the plurality of two-dimensional images, generating a synthetic two-dimensional image based on the number of indicators and at least one of the plurality of two-dimensional images, providing the synthetic two-dimensional image to a second model including a second trained neural network, receiving a malignancy likelihood score from the second model, and outputting a report including the malignancy likelihood score to at least one of a memory or a display.