Patents Assigned to Defiante Farmaceutica, S.A.
  • COMBINATION COMPOSITION USEFUL FOR TREATING CARDIOVASCULAR DISEASES
    Publication number: 20130236551
    Abstract: It is described the use of a combination consisting of a microcapsule suspension comprising one or more statins in alkyl esters of n-3 PUFA in which the statins are isolated from contact with the alkyl ester of n-3 PUFA by means of a polymeric membrane that can be easily disintegrated in the gastrointestinal medium, for the treatment of cardiovascular diseases.
    Type: Application
    Filed: November 30, 2010
    Publication date: September 12, 2013
    Applicant: DEFIANTE FARMACEUTICA .S.A.
    Inventors: Anna Atti, Enrico Cavazza, Silvia Cavazza, Francesca Cavazza, Martina Cavazza Preta
  • Compounds having antitumor activity
    Patent number: 8314144
    Abstract: Disclosed is the use of compounds of formula (I) wherein X, Y and Z are as defined in the description of the invention, for the preparation of an antitumor medicament, optionally in combination with different biologically active substances.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: November 20, 2012
    Assignee: Defiante Farmaceutica, S.A.
    Inventors: Gianfranco Peluso, Menotti Calvani
  • Stable recombinant adenosine deaminase
    Patent number: 8071741
    Abstract: A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: December 6, 2011
    Assignee: Defiante Farmaceutica, S.A.
    Inventors: David R. Filpula, Stephen K. Youngster
  • RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II
    Publication number: 20100273236
    Abstract: The invention provides a recombinant Escherichia coli host cell for producing an Escherichia coli L-asparaginase II enzyme. The host cell includes an Escherichia coli chromosome and at least one copy of a recombinant extrachromosomal vector, wherein the recombinant extrachromosomal vector encodes the L-asparaginase II enzyme, wherein the host cell chromosome also encodes the same L-asparaginase II enzyme, and wherein the host chromosome does not encode any other isoform of L-asparaginase II.
    Type: Application
    Filed: May 4, 2010
    Publication date: October 28, 2010
    Applicant: DEFIANTE FARMACEUTICA, S.A.
    Inventors: David Ray FILPULA, Maoliang WANG
  • Recombinant host for producing L-asparaginase II
    Patent number: 7807436
    Abstract: The invention provides a recombinant Escherichia coli host cell for producing an Escherichia coli-asparaginase II enzyme. The host cell includes an Escherichia coli chromosome and at least one copy of a recombinant extrachromosomal vector, wherein the recombinant extrachromosomal vector encodes the L-asparaginase II enzyme, wherein the host cell chromosome also encodes the same L-asparaginase II enzyme, and wherein the host chromosome does not encode any other isoform of L-asparaginase II.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: October 5, 2010
    Assignee: Defiante Farmaceutica, S.A.
    Inventors: David Ray Filpula, Maoliang Wang