Abstract: The invention relates to an implantable chamber comprising a closed shell made of a permeable membrane, said membrane comprising at least one layer of porous biocompatible polymer, with pores controlled and homogeneously distributed over the membrane.
Type:
Application
Filed:
April 8, 2021
Publication date:
May 25, 2023
Applicant:
Defymed
Inventors:
Charles-Thibault Burcez, Richard Bou Aoun, Séverine Sigrist
Abstract: The invention relates to a heparin-functionalized semi-permeable membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer wherein said heparin is covalently bound to a layer on the surface of said porous biocompatible polymer.
Type:
Grant
Filed:
May 17, 2016
Date of Patent:
October 27, 2020
Assignee:
Defymed
Inventors:
Richard Bou Aoun, Charles-Thibault Burcez, Jordan Magisson, Séverine Sigrist
Abstract: The invention relates to a chamber (100) for encapsulating secreting cells producing at least one substance of interest, the chamber comprising: —an upper washer (120) and a bottom washer (110) configured to be oppositely placed on a side and on another side of two semi-permeable membranes (141, 142), —optionally at least one intermediate washer (130), provided between both membranes, in a plane sensibly parallel to upper and bottom washers planes and delimiting two superposed half cells spaces (S1, S2) capable of containing the secreting cells producing the at least one substance of interest, —optionally sealing means (150) the upper and the bottom washers (120, 110) being tightly clipped together, incorporating the intermediate washer (130) therebetween.
Type:
Application
Filed:
July 10, 2018
Publication date:
May 21, 2020
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Charles-Thibault Burcez, Jordan Magisson, Séverine Sigrist, Nicolas Faivre, Clément Leonard, Sébastien Perrot
Abstract: The present invention relates to an implantable pouch which contains a rigid plate in its inner volume, thereby preventing said pouch to be folded.
Type:
Application
Filed:
July 10, 2018
Publication date:
May 14, 2020
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Charles-Thibault Burcez, Jordan Magisson, Séverine Sigrist
Abstract: The invention relates to a kit for delivering a compound of interest in situ to a patient in need thereof, comprising a chamber comprising a closed shell made of the semi-permeable membrane, the pouch comprising at least one connector comprising a body attached to the sheet, and a catheter that can be connected to said connector at one end and that can be connected to a source of delivery of a compound of interest at the other end, as well as methods of use of such kit.
Type:
Application
Filed:
November 7, 2017
Publication date:
August 22, 2019
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Severine Sigrist, Charles-Thibault Burcez
Abstract: The invention relates to an encapsulating chamber for secreting cells, comprising a closed shell made of a semi-permeable membrane, said membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer.
Type:
Application
Filed:
July 10, 2018
Publication date:
November 1, 2018
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Severine Sigrist, Stefan Sproll
Abstract: The invention relates to a heparin-functionalized semi-permeable membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer wherein said heparin is covalently bound to a layer on the surface of said porous biocompatible polymer.
Type:
Application
Filed:
May 17, 2016
Publication date:
May 31, 2018
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Charles-Thibault Burcez, Jordan Magisson, Séverine Sigrist
Abstract: The invention relates to an encapsulating chamber for secreting cells, comprising a closed shell made of a semi-permeable membrane, said membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer.
Type:
Application
Filed:
December 9, 2014
Publication date:
October 27, 2016
Applicant:
Defymed
Inventors:
Richard Bou Aoun, Severine Sigrist, Stefan Sproll