Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: A method for optimal selection of cytotoxic agents for organ or region specific therapy that includes extracorporeal filtration of the cytotoxic agent from blood drained from the organ or region being treated and return of the filtered blood to a mammal is disclosed.

Abstract: Provided is a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media held in a housing for holding the two or more filter cartridges in about the same orientation, and an attachment clamp connected to the housing. Also provided is a housing for holding two or more filter cartridges in about the same orientation and a method of using the filter apparatus and housing.

Abstract: Provided is a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media held in a housing for holding the two or more filter cartridges in about the same orientation, and an attachment clamp connected to the housing. Also provided is a housing for holding two or more filter cartridges in about the same orientation and a method of using the filter apparatus and housing.

Abstract: A filter apparatus for removing contaminants from a fluid and having an internal chamber with an adjustable volume is provided. Filter media priming to dislodge trapped gas is facilitated by the filter apparatus. A method of priming a filter cartridge containing a filter media is also provided.

Abstract: Provided is a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media held in a housing for holding the two or more filter cartridges in about the same orientation, and an attachment clamp connected to the housing. Also provided is a housing for holding two or more filter cartridges in about the same orientation and a method of using the filter apparatus and housing.

Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: The instant invention encompasses a catheter, comprising: a first expandable occlusion device and a second expandable occlusion device, expandable beyond a wall of the catheter, the first occlusion device and the second occlusion device spaced along the catheter for generating an occluded segment of the blood vessel between the first occlusion device and the second occlusion device when the first occlusion device and the second occlusion device are expanded, a lumen or catheter for removing uncontaminated blood from a location up-stream of a first expandable occlusion device; a lumen or catheter for reintroducing the uncontaminated blood into a subject downstream from the second expandable occlusion device; apparati encompassing the above technology; and methods of use incorporating same.

Abstract: The instant invention provides a novel double balloon catheter which includes a first fixed balloon on the cranial end of the catheter; a second slidable balloon positioned around the catheter and spaced from the first fixed balloon; and, structure for enabling the second balloon to slide along the plastic tube between a first position defining a minimum distance between the first balloon and the second balloon, and a second position defining a maximum distance between the first balloon and the second balloon. The invention also contemplates a novel method of using the catheter.

Abstract: An arrangement for controlling the flow of blood between the annulus between a catheter and an elastomeric tube which encases it is provided. The arrangement also controls the ease of lateral movement of the catheter in relationship to the elastomeric tube. The arrangement includes a substantially rigid telescoping tube for supporting the elastomeric tube therewithin. The rigid telescoping tube further includes an inner tube having a pin disposed on the outer circumference thereof; and an outer tube having an opening therein forming a slot, and a plurality of substantially equally spaced stops; a first clamping arrangement for fixing one end of the elastomeric tube to the end of the outer tube furthest from the inner tube; and, a second clamping arrangement for fixing the other end of the elastomeric tube to the end of the inner tube furthest from the outer tube.

Abstract: An improved balloon catheter with an inferior vena cava blood shunt or bypass is provided. Posterior and anterior ports in the wall of the catheter connect to a common lumen within the catheter, forming a shunt or bypass for blood flowing in the blood vessel. The blood shunt or bypass spans the blockage in the blood vessel generated by enlargement of the balloons of the balloon catheter. Bypass port closure apparatus is provided which is operated at the external end of the catheter. The bypass port closure device functions to open and close at least one of the ports of the bypass, effectively opening and closing the bypass.

Abstract: The instant invention provides a novel apparatus, kit and process for isolating a flow circuit within the pelvic cavity of a patient for perfusing a high concentration of a chemotherapeutic agent therethrough, without contaminating the blood circulating in the substantial remainder of the patient's blood circulatory system with the agent.

Abstract: Perfusing a high concentration of an agent to treat an organ, such as anti-cancer agents through a body organ containing a tumor, without their entering the body's general circulation, removing them from the organ with effluent blood and transporting the contaminated blood to an extracorporeal circuit where the blood is treated to remove the contamination, and returning the treated blood to the body. The process prevents toxic levels of the agents from entering the body's general circulation while delivering lethal doses of the agents to the tumor. There are described various apparatus for effecting the intra- and extracorporeal treatment of such contaminated blood.