Abstract: The invention provides a method and apparatus for classifying a region of interest in imaging data, the method comprising: calculating a feature vector for at least one region of interest in the imaging data; projecting the feature vector for the at least one region of interest in the imaging data using a plurality of decision functions to generate a corresponding plurality of classifications; calculating an ensemble classification based on the plurality of classifications. receiving from the user feedback information concerning the ensemble classification; forming an additional classified feature vector from the feature vector and the feedback information; and updating at least one of the plurality of decision functions using the additional classified feature vector.