Patents Assigned to Delphinus Medical Technologies, Inc.
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Publication number: 20230215005Abstract: Described herein are systems, devices, and methods for aiding a user to scroll through or otherwise manipulate a stack of medical and tissue images. A system as described herein may comprise: a foot controller, configured to detect one or more of vertical and horizontal motion of a user’s foot to control image navigation, review, positioning, and viewing, functions; a computer; and a user interface.Type: ApplicationFiled: March 15, 2023Publication date: July 6, 2023Applicant: Delphinus Medical Technologies, Inc.Inventors: Mark Forchette, John Seamans
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Publication number: 20230089236Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: June 28, 2022Publication date: March 23, 2023Applicant: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 11399798Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: December 12, 2018Date of Patent: August 2, 2022Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 11350905Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: GrantFiled: June 18, 2019Date of Patent: June 7, 2022Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter J. Littrup, Gursharan Singh Sandhu, Mark Krycia, Mark Sak
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Patent number: 11298111Abstract: A method and system for generating an enhanced image of a volume of tissue, comprising: emitting acoustic waveforms toward the volume of tissue; detecting acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating a reflection rendering of a region of the volume of tissue; generating at least one of a sound speed map and an attenuation map of the region of the volume of tissue; generating a transfer map derived from a set of sound speed parameter values of the sound speed map and/or a set of acoustic attenuation parameter values of the acoustic attenuation map, the set of sound speed parameter values and the set of acoustic attenuation parameters associated with the set of elements of the region of the volume of tissue; and rendering an enhanced image of the volume of tissue, derived from processing of the reflection rendering with the transfer map.Type: GrantFiled: March 29, 2019Date of Patent: April 12, 2022Assignee: DELPHINUS MEDICAL TECHNOLOGIES, INC.Inventors: Nebojsa Duric, Peter Littrup, Cuiping Li
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Patent number: 11298105Abstract: A tissue positioning system for contouring a patient tissue volume includes an axially displaceable interface having a surface configured to engage a breast or other tissue volume. A low pressure source applies a partial low pressure to the surface of the displaceable interface to secure the tissue volume to the surface, and the axially displaceable interface is biased to pull and contour the tissue volume when the tissue volume is secured to the surface. The axially displaceable interface is typically mounted on a telescoping support and the biasing is provided by the same low pressure used to secure the tissue volume.Type: GrantFiled: September 6, 2018Date of Patent: April 12, 2022Assignee: Delphinus Medical Technologies, Inc.Inventors: Ron Ho, Peter Littrup, Nebojsa Duric
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Patent number: 11147537Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.Type: GrantFiled: November 7, 2018Date of Patent: October 19, 2021Assignee: DELPHINUS MEDICAL TECHNOLOGIES, INC.Inventors: Nebojsa Duric, Peter Littrup, Cuiping Li, Olivier Roy, Steven Schmidt
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Patent number: 11071520Abstract: This application presents a system and related methods that analyze a volume of tissue using ultrasound waveform tomography imaging. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, the system can reconstruct the sound speed distributions of a volume of tissue, such as breast tissue, of varying densities with different types of lesions. By allowing sound speed to have an imaginary component that characterizes sound attenuation, the system can classify the different types of lesions with a fine granularity.Type: GrantFiled: March 1, 2018Date of Patent: July 27, 2021Assignee: Delphinus Medical Technologies, Inc.Inventors: Gursharan Singh Sandhu, Nebojsa Duric, Cuiping Li, Olivier Roy, Erik West
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Patent number: 11064974Abstract: A patient interface system for scanning a volume of tissue protruding from a patient, the system comprising: a base including a planar portion configured to support the patient in a prone configuration, and a frustoconical portion extending from the planar portion and defining a base aperture configured to receive the volume of tissue; and a support assembly configured to couple to the base, including a frame and a membrane retained in tension within the frame at a peripheral portion of the membrane, wherein the membrane defines a membrane aperture configured to align with the base aperture, and wherein the membrane is configured to deflect into the frustoconical portion of the base in response to the patient's weight. The system can further include an electrical subsystem including a pressure sensor array configured to generate signals in response to a pressure distribution resulting from the patient's weight at the patient interface system.Type: GrantFiled: October 9, 2018Date of Patent: July 20, 2021Assignee: Delphinus Medical Technologies, Inc.Inventors: James Szpak, Nebojsa Duric, Peter Littrup, Roman Janer, Mike Tesic
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Patent number: 10898164Abstract: A tissue positioning system for contouring a patient tissue volume includes an axially displaceable interface having a surface configured to engage a breast or other tissue volume. A low pressure source applies a partial low pressure to the surface of the displaceable interface to secure the tissue volume to the surface, and the axially displaceable interface is biased to pull and contour the tissue volume when the tissue volume is secured to the surface. The axially displaceable interface is typically mounted on a telescoping support and the biasing is provided by the same low pressure used to secure the tissue volume.Type: GrantFiled: February 8, 2017Date of Patent: January 26, 2021Assignee: Delphinus Medical Technologies, Inc.Inventors: Ron Ho, Peter Littrup, Nebojsa Duric
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Patent number: 10743837Abstract: A method and system for generating an enhanced image of a volume of tissue, the method comprising: emitting acoustic waveforms toward the volume of tissue; detecting a set of acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating, from the set of acoustic signals, an initial model representing a distribution of an acoustomechanical parameter across a region of the volume of tissue; extracting a set of frequency components, from the set of acoustic signals; generating a first simulated wavefield with a first frequency component of the set of frequency components; generating an updated model of the initial model with the first simulated wavefield; iteratively refining the updated model with a set of simulated wavefields associated with the set of frequency components until a threshold condition is satisfied, thereby producing a final model; and generating the enhanced image from the final model of the volume of tissue.Type: GrantFiled: August 4, 2015Date of Patent: August 18, 2020Assignee: Delphinus Medical Technologies, Inc.Inventors: Gursharan Singh Sandhu, Cuiping Li, Olivier Roy, Steven Schmidt, Nebojsa Duric
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Patent number: 10368831Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: GrantFiled: December 1, 2017Date of Patent: August 6, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter J. Littrup, Gursharan Singh Sandhu, Mark Krycia, Mark Sak
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Patent number: 10285667Abstract: A method and system for generating an enhanced image of a volume of tissue, comprising: emitting acoustic waveforms toward the volume of tissue; detecting acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating a reflection rendering of a region of the volume of tissue; generating at least one of a sound speed map and an attenuation map of the region of the volume of tissue; generating a transfer map derived from a set of sound speed parameter values of the sound speed map and/or a set of acoustic attenuation parameter values of the acoustic attenuation map, the set of sound speed parameter values and the set of acoustic attenuation parameters associated with the set of elements of the region of the volume of tissue; and rendering an enhanced image of the volume of tissue, derived from processing of the reflection rendering with the transfer map.Type: GrantFiled: August 5, 2015Date of Patent: May 14, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter Littrup, Cuiping Li
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Patent number: 10278672Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: GrantFiled: August 25, 2015Date of Patent: May 7, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Peter John Littrup, Nebojsa Duric
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Patent number: 10251622Abstract: A system for providing scanning medium for scanning a volume of tissue comprising: an inner chamber that contains the scanning medium; a transducer mounted to the inner chamber and configured to move along a motion path, with the inner chamber, in scanning the volume of tissue; an outer chamber concentrically aligned about the inner chamber to guide the inner chamber along the motion path; a piston module defining a base surface within the inner chamber, the piston module comprising a medium inlet and a medium outlet for adjusting an amount of the scanning medium within the inner chamber; a detection subsystem coupled to the base surface of the piston module; and an actuator comprising a stationary portion mounted to the piston module and a moving portion coupled to the inner chamber and configured to produce motion of the inner chamber along the motion path.Type: GrantFiled: August 27, 2018Date of Patent: April 9, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Mike Tesic, Marc Orloff, Kevin Obrigkeit, David Kunz, Roman Janer
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Publication number: 20190083060Abstract: A tissue positioning system for contouring a patient tissue volume includes an axially displaceable interface having a surface configured to engage a breast or other tissue volume. A low pressure source applies a partial low pressure to the surface of the displaceable interface to secure the tissue volume to the surface, and the axially displaceable interface is biased to pull and contour the tissue volume when the tissue volume is secured to the surface. The axially displaceable interface is typically mounted on a telescoping support and the biasing is provided by the same low pressure used to secure the tissue volume.Type: ApplicationFiled: September 6, 2018Publication date: March 21, 2019Applicant: Delphinus Medical Technologies, Inc.Inventors: Ron Ho, Peter Littrup, Nebojsa Duric
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Patent number: 10231696Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: October 12, 2017Date of Patent: March 19, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 10201324Abstract: A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.Type: GrantFiled: September 15, 2014Date of Patent: February 12, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Carri Glide-Hurst, Nebojsa Duric, Peter Littrup
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Patent number: 10143443Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.Type: GrantFiled: May 4, 2015Date of Patent: December 4, 2018Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter Littrup, Cuiping Li, Olivier Roy, Steven Schmidt
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Patent number: 10123770Abstract: A system for supporting a patient while scanning a volume of tissue protruding from a patient includes a base having a planar portion configured to support the patient in a prone configuration. A frustoconical portion extends from the planar portion and defines a base aperture configured to receive the volume of tissue. A support assembly couples to the base. A membrane is retained in tension within a frame at a peripheral portion of the membrane. The membrane defines a membrane aperture configured to align with the base aperture, and the membrane is configured to deflect into the frustoconical portion of the base in response to the patient's weight. The system can further include an electrical subsystem including a pressure sensor array configured to generate signals in response to a pressure distribution resulting from the patient's weight at the patient interface system.Type: GrantFiled: March 13, 2014Date of Patent: November 13, 2018Assignee: Delphinus Medical Technologies, Inc.Inventors: James Szpak, Nebjosa Duric, Peter Littrup, Roman Janeer, Mike Tesic