Patents Assigned to Delsys Pharmaceutical
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Publication number: 20040179322Abstract: The invention is directed to a corona charging device having a powder feed with an outlet. The device has an internal charging cavity having an inlet and a charged powder outlet. The powder feed outlet is positioned at the internal charging cavity inlet. The device is adapted to guide a powder stream downstream from the powder feed outlet to the charged powder outlet. The device also includes a corona charger having one or more needle projections (each having a tip) positioned and adapted to facilitate a corona ion flow from the needle projections and intersecting the powder stream. The device also includes a rotating ground electrode adapted to be charged or grounded to attract the corona flow from the needle projections, and to rotate segments of the ground electrode between the internal charging cavity and a ground electrode cleaner.Type: ApplicationFiled: March 11, 2003Publication date: September 16, 2004Applicant: Sarnoff Corporation Delsys PharmaceuticalInventors: Timothy Allen Pletcher, David Keller, Wen Ho, Eugene Samuel Poliniak, John Paul Furda, Joseph Thomas McGinn, Donald Chester Pultorak, Mortaza Kashef
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Patent number: 6752148Abstract: An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels.Type: GrantFiled: September 1, 2000Date of Patent: June 22, 2004Assignee: Delsys Pharmaceutical CompanyInventors: Joseph T. McGinn, Suggy S. Chrai, Bogdan Brycki, Bawa Singh, Peter Coyle, Gary Santonastaso, Hoi Cheong Sun
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Publication number: 20040115276Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: ApplicationFiled: March 28, 2003Publication date: June 17, 2004Applicant: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Patent number: 6724609Abstract: Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (Ea) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.Type: GrantFiled: January 4, 2002Date of Patent: April 20, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Nitin V. Desai, William R. Roach, David Norman Ludington, Timothy Allen Pletcher, David Keller, Frank B. Lang, Peter D. Southgate, Joseph T. McGinn
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Patent number: 6720024Abstract: Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; and an optical detection device for quantifying the amount of grains deposited.Type: GrantFiled: November 27, 2002Date of Patent: April 13, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, Peter Zanzucchi, David Keller, Dominic Stephen Rosati
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Patent number: 6702803Abstract: Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.Type: GrantFiled: January 22, 2001Date of Patent: March 9, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Gary Kupperblatt, Marc S. Karetny, Ramaswamy Murari, Suggy S. Chrai
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Patent number: 6670038Abstract: The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image.Type: GrantFiled: June 17, 2002Date of Patent: December 30, 2003Assignee: Delsys PharmaceuticalInventors: Hoi Cheong Steve Sun, Timothy Allen Pletcher
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Publication number: 20030200922Abstract: Provided, among other things, is a re-circulating particle feed apparatus comprising: a circular conduit of dimensions suitable for circulating gas with suspended particles; a deposition station comprising an opening onto the conduit, into which opening an electrostatic chuck fits, with a deposition surface of the chuck available to the interior of the conduit; and a propulsion device for maintaining fluid and particle circulation through the conduit, wherein the propulsion device is adapted to maintain fluid and particle circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station.Type: ApplicationFiled: April 29, 2003Publication date: October 30, 2003Applicant: Delsys Pharmaceutical CorporationInventors: George R. Pawlo, Gary Santonastaso, David Keller, Ramaswamy Murari, Suggy S. Chrai
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Publication number: 20030196599Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising:Type: ApplicationFiled: April 25, 2003Publication date: October 23, 2003Applicant: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Bogdan Brycki
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Patent number: 6630027Abstract: Provided, among other things, is a re-circulating particle feed apparatus comprising: a circular conduit of dimensions suitable for circulating gas with suspended particles; a deposition station comprising an opening onto the conduit, into which opening an electrostatic chuck fits, with a deposition surface of the chuck available to the interior of the conduit; and a propulsion device for maintaining fluid and particle circulation through the conduit, wherein the propulsion device is adapted to maintain fluid and particle circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station.Type: GrantFiled: July 11, 2001Date of Patent: October 7, 2003Assignee: Delsys Pharmaceutical CorporationInventor: George R. Pawlo
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Patent number: 6616932Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: GrantFiled: September 23, 1999Date of Patent: September 9, 2003Assignee: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Patent number: 6591833Abstract: In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament.Type: GrantFiled: February 13, 2001Date of Patent: July 15, 2003Assignee: Delsys Pharmaceutical Corp.Inventors: Pabitra Datta, Howard Christopher Rivenburg, Nitin Desai
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Patent number: 6592671Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.Type: GrantFiled: January 25, 2001Date of Patent: July 15, 2003Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Bogdan Brycki
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Patent number: 6578607Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the “boundary layer” near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots.Type: GrantFiled: December 10, 2001Date of Patent: June 17, 2003Assignee: Delsys Pharmaceutical Corp.Inventors: Kerry Dennis O'Mara, David Keller, Joseph Thomas McGinn
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Publication number: 20030087023Abstract: The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image.Type: ApplicationFiled: June 17, 2002Publication date: May 8, 2003Applicant: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Timothy Allen Pletcher
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Patent number: 6527138Abstract: A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamplike (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing.Type: GrantFiled: April 15, 2002Date of Patent: March 4, 2003Assignee: Delsys Pharmaceutical Corp.Inventors: George R. Pawlo, Gary Santonastaso, Ramaswamy Murari, Suggy Chrai
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Patent number: 6511712Abstract: Provided is a method using a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; and an optical detection device for quantifying the amount of grains deposited.Type: GrantFiled: March 21, 2000Date of Patent: January 28, 2003Assignee: Delsys PharmaceuticalInventors: Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, Peter Zanzucchi, David Keller, Dominic Stephen Rosati
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Patent number: 6491241Abstract: Provided is, among other things, and together with associated methods, a powder feed comprising: a venturi comprising an external gas inlet, a gas outlet through which gas flows at a rate amplified over a gas flow rate into the external gas inlet, and an internal gas inlet; and a cyclone with an intake port connected to the venturi gas outlet, a recycle outlet port, and a product port, wherein a gas flow rate FS into the venturi external gas inlet results in an enhanced flow rate into the cyclone intake port.Type: GrantFiled: October 14, 1999Date of Patent: December 10, 2002Assignee: Delsys Pharmaceutical CorporationInventor: Hoi Cheong Sun
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Patent number: 6475351Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.Type: GrantFiled: January 30, 2001Date of Patent: November 5, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Dominic Stephen Rosati, Eugene Samuel Puliniak, Bawa Singh, Nitin Vithalbhai Desai
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Patent number: 6444033Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the “boundary layer” near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots.Type: GrantFiled: November 12, 1999Date of Patent: September 3, 2002Assignee: Delsys Pharmaceutical Corp.Inventors: Kerry Dennis O'Mara, David Keller, Joseph Thomas McGinn