Abstract: Methods for treating and/or alleviating acute respiratory distress syndrome in an individual diagnosed with or at risk of developing acute respiratory distress syndrome are disclosed. The methods comprise administering a therapeutically effective amount of a complement inhibitor or a TNF-alpha inhibitor to the individual, wherein the complement inhibitor or the TNF-alpha inhibitor reduces or prevents tissue factor production in alveolar neutrophils, thereby treating the ARDS, or delaying or preventing onset of ARDS.
Type:
Application
Filed:
July 17, 2008
Publication date:
June 16, 2011
Applicants:
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, DEMOCRITUS UNIVESITY OF THRACE