Abstract: Methods and devices for preparing a biological sample for analysis are described. The biological sample from an organism has at least macromolecule having a primary structure that naturally degrades after the sample is removed from the organism. The method includes causing the biological sample to adopt a shape to permit rapid and uniform heating. The shaped sample is then rapidly and uniformly heated, thereby altering a secondary structure of the macromolecule while preserving its primary structure.

Abstract: The present invention provides methods for stabilizing a biological sample for analysis. The invention more particularly provides methods combining heat treatment and chemical fixation of biological samples in order to maintain protein primary structure and post-translational modifications, such as protein phosphorylations.

Abstract: The present invention provides methods for stabilizing a biological sample for analysis. The invention more particularly provides methods combining heat treatment and chemical fixation of biological samples in order to maintain protein primary structure and post-translational modifications, such as protein phosphorylations.

Abstract: A device for storing a biological sample (3) and allowing transfer of heat for disrupting secondary structures of the biological sample (3) is disclosed. It comprises a biological sample carrier (5) having a portion (7). The portion (7) is intended for receiving a biological sample (3). It also comprises at least one sealing means (9, 13, 15) for sealing the portion (7), a heat transfer segment (11) that extends at least essentially through at least one of the portion (7) and the sealing means (9, 13, 15), and presents a ratio between a heat conductivity of and a thickness of the heat transfer segment (11) that is larger than 500 W/m K in order to enable heat transfer to the biological sample (3) via the heat transfer segment (11). Also, a method for preparing the biological sample (3) is disclosed.