Patents Assigned to Dendritech Inc.
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Patent number: 6635720Abstract: Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendritic polymer molecule having a plurality of terminal functional groups of a first type which are not reactive with each other, and a plurality of shell dendritic polymer molecules having a plurality of terminal functional groups of a second type which are not reactive with each other, but which are reactive with the terminal functional groups of the first type. Each of the shell dendritic polymer molecules is chemically bonded to the core dendritic polymer molecule by a reaction of at least one of the terminal functional groups of the second type with at least one of the terminal functional groups of the first type.Type: GrantFiled: January 24, 2002Date of Patent: October 21, 2003Assignee: Dendritech Inc.Inventors: Donald A. Tomalia, Srinivas Uppuluri, Douglas R. Swanson, Herbert M. Brothers, II
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Patent number: 6043336Abstract: An electrically conductive polymer is comprised of the reaction product of a dendrimer and an electrophoric compound which exhibits .pi.-stacking upon reduction. The reaction product which is a peripherally modified dendrimer is formed and reduced, either chemically or electrochemically, in a polar solvent. The reduced electrophoric moieties aggregate (form .pi.-stacks) to form electrically conductive pathways. The reduced peripherally modified dendrimers of the invention can be cast into films and other solid forms to provide flexible electrical conductors and semiconductors. The conductive polymers of the invention exhibit electrical conductivities comparable to that of doped polyacetalene, but are oxygen and moisture stable.Type: GrantFiled: January 26, 1998Date of Patent: March 28, 2000Assignee: Dendritech, Inc.Inventors: Larry L. Miller, Donald A. Tomalia, Robert G. Duan
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Patent number: 6020457Abstract: Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound.Type: GrantFiled: September 30, 1997Date of Patent: February 1, 2000Assignee: Dendritech Inc.Inventors: June W. Klimash, Herbert M. Brothers, II, Douglas R. Swanson, Rui Yin, Ralph Spindler, Donald A. Tomalia, Yong Hsu, Roberta C. Cheng
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Patent number: 5938934Abstract: Dendritic polymer based networks consisting of well-defined hydrophilic and oleophilic (i.e., hydrophobic) domains, are capable of performing as nanoscopic sponges for electrophilic guest moieties such as (i) inorganic and organic cations; (ii) charged or polarized molecules containing electrophilic constituent atoms or atomic groups; and (iii) other electrophilic organic, inorganic, or organometallic species. As a result of such performance, the networks yield novel nanoscopic organo-inorganic composites which contain organosilicon units as an integral part of their covalently bonded matrix.Type: GrantFiled: January 13, 1998Date of Patent: August 17, 1999Assignees: Dow Corning Corporation, Dendritech Inc.Inventors: Lajos Balogh, Agnes M. deLeuze-Jallouli, Petar R. Dvornic, Michael J. Owen, Susan Victoria Perz, Ralph Spindler
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Patent number: 5919442Abstract: A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.Type: GrantFiled: August 9, 1996Date of Patent: July 6, 1999Assignees: Dendritech, Inc., University of MichiganInventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson, James R. Baker, Jr., Jolanta F. Kukowska-Latallo
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Patent number: 5773527Abstract: This invention discloses non-crosslinked, poly-branched polymers having a comb-burst configuration and a process for preparing such polymers.Type: GrantFiled: January 20, 1995Date of Patent: June 30, 1998Assignee: Dendritech, Inc.Inventors: Donald A. Tomalia, David M. Hedstrand, Rui Yin
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Patent number: 5631329Abstract: The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.Type: GrantFiled: March 21, 1995Date of Patent: May 20, 1997Assignee: Dendritech, Inc.Inventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson