Patents Assigned to DeNovix Inc.
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Publication number: 20240066518Abstract: Broad volumetric range pipettes with multi-tiered pipette tip holder and ejection assemblies and methods of using such pipettes are disclosed herein. These pipettes typically include a concentric cylinder arrangement with each outer cylinder configured for contacting and dislodging a pipette tip attached to the tip holder portion of the immediately adjacent inner cylinder. In this manner, different sized pipette tips can be used on a single device. In addition, a locking mechanism is described for locking the large tip holder into a downward position to minimize the extension of the small tip holder and thereby enabling attachment of large, filtered pipette tips and reducing/eliminating the risk that the liquid being transferred will contaminate the pipetting device.Type: ApplicationFiled: August 29, 2023Publication date: February 29, 2024Applicant: DeNovix Inc.Inventors: Benayah Ben-Avraham, Daniel Schieffer, David L. Ash, Fernando Frederick Kielhorn, David B. Ward
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Patent number: 11679383Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.Type: GrantFiled: July 27, 2022Date of Patent: June 20, 2023Assignee: DeNovix, IncInventors: Daniel A. Schieffer, David L. Ash, David B. Ward
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Patent number: 11660592Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.Type: GrantFiled: February 12, 2021Date of Patent: May 30, 2023Assignee: DeNovix, Inc.Inventors: Daniel A. Schieffer, David L. Ash, David B. Ward
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Publication number: 20220362759Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.Type: ApplicationFiled: July 27, 2022Publication date: November 17, 2022Applicant: DENOVIX, INC.Inventors: Daniel A. Schieffer, David L. Ash, David B. Ward
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Publication number: 20210252496Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.Type: ApplicationFiled: February 12, 2021Publication date: August 19, 2021Applicant: DENOVIX, INC.Inventors: Daniel A. SCHIEFFER, David L. Ash, David B. Ward
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Patent number: 10598598Abstract: Cell counters and methods of their use are disclosed herein. The cell counters include a sample mounting system that includes a base, which includes a mounted lower sample surface and a cover having a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.Type: GrantFiled: April 23, 2019Date of Patent: March 24, 2020Assignee: Denovix, Inc.Inventors: Fernando F. Kielhorn, Daniel A. Schieffer, David L. Ash, Kevin Kelley, Andrew William Jones
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Publication number: 20190310197Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.Type: ApplicationFiled: April 23, 2019Publication date: October 10, 2019Applicant: Denovix, Inc.Inventors: Fernando F. Kielhorn, Daniel A. Schieffer, David L. Ash, Kevin Kelley, Andrew William Jones
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Patent number: 10302568Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.Type: GrantFiled: June 20, 2017Date of Patent: May 28, 2019Assignee: Denovix, Inc.Inventors: Fernando F. Kielhorn, Daniel A. Schieffer, David L. Ash, Kevin Kelley
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Patent number: 9442009Abstract: An improved apparatus and method for making optical measurements of a sample is described. In one embodiment, the apparatus is a microvolume sampling mechanism comprised of two opposing optical measurement surfaces. A sample is held by surface tension between the two opposing optical measurement surfaces. Light is transmitted through the sample and received by optical fibers, which measure the absorbance of the sample. This absorbance can be used to determine the concentration of the sample.Type: GrantFiled: February 14, 2014Date of Patent: September 13, 2016Assignee: DeNovix, Inc.Inventors: Fernando F. Kielhorn, David B. Ward
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Publication number: 20150233760Abstract: An improved apparatus and method for making optical measurements of a sample is described. In one embodiment, the apparatus is a microvolume sampling mechanism comprised of two opposing optical measurement surfaces. A sample is held by surface tension between the two opposing optical measurement surfaces. Light is transmitted through the sample and received by optical fibers, which measure the absorbance of the sample. This absorbance can be used to determine the concentration of the sample.Type: ApplicationFiled: February 14, 2014Publication date: August 20, 2015Applicant: DeNovix Inc.Inventors: Fernando F. KIELHORN, David B. Ward