Abstract: A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.
Type:
Grant
Filed:
December 13, 1991
Date of Patent:
September 21, 1993
Assignees:
Ludwig Institute for Cancer Research, Department d'Immunologie Institut Henri Beaufour
Inventors:
Bernard Dugas, Catherine Druez, Pierre Braquet, Jean M. Mencia-Huerta, Catherine Uyttenhove, Jean-Christophe Renauld, Jacques Van Snick