Patents Assigned to Department Of Health And Human Services, Govt. of the United States of America
  • Process for preparing polysaccharide-protein conjugate vaccines
    Publication number: 20070110762
    Abstract: Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
    Type: Application
    Filed: August 6, 2004
    Publication date: May 17, 2007
    Applicant: Department Of Health And Human Services, Govt. of the United States of America
    Inventors: Ellen Jessouroun, Ivna Brasileiro Da Silveira, Renata Bastos, Carl Frasch, Che-Hung Lee