Patents Assigned to Department of Medical Sciences Ministry of Public Health of Thailand
  • Recombinant BCG vaccine
    Patent number: 7670610
    Abstract: A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: March 2, 2010
    Assignee: Department of Medical Sciences-Ministry of Public Health of Thailand
    Inventors: Mitsuo Honda, Kazuhiro Matsuo, Masaru Kanekiyo, Duanthanorm Promkhatkaew
  • Recombinant BCG vaccine
    Patent number: 7638133
    Abstract: A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: December 29, 2009
    Assignee: Department of Medical Sciences Ministry of Public Health of Thailand
    Inventors: Mitsuo Honda, Kazuhiro Matsuo, Masaru Kanekiyo, Duanthanorm Promkhatkaew