Abstract: The present invention relates to a multichannel imaging device and more specifically to a multichannel device wherein each optical channel has at least an optical low-pass angular filter configured to block any light propagating through the optical channel along a direction of propagation having an angle which is greater than a predefined angle ?L relative to the optical axis, the low-pass angular filter comprising at least one planar interface, separating a first material having a first refractive index n1 and a second material having a second refractive index n2, the ratio of the second refractive index over the first refractive index being lower than 1, preferably lower than 0.66.

Abstract: Disclosed herein are methods of screening candidate binding compounds to a plurality of target nucleic acids either of the same sequence or of different sequences utilizing a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to various candidate binding compounds. In the presence of a plurality of nucleic acid sequences, the methods described herein also can rapidly determine the specificity of the small molecule or polypeptide to a nucleic acid structure. Also, disclosed herein are methods of measuring binding kinetics of binding compounds to a target nucleic acid using a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to varying concentrations of the candidate binding compound.

Abstract: A device for optically imaging at least a part of an object, the device having an optical axis and including a two-dimensional first array of first microlenses, having a first side intended to face the object, and a second side, opposite the first side, a two-dimensional second array of second microlenses, each first microlens being aligned with a second microlens on an axis parallel to the optical axis, wherein each first microlens comprises a first catoptric system, and preferably a first catadioptric system.

Abstract: The present invention relates to a multichannel imaging device and more specifically to a multichannel device wherein each optical channel has at least an optical low-pass angular filter configured to block any light propagating through the optical channel along a direction of propagation having an angle which is greater than a predefined angle ?L relative to the optical axis, the low-pass angular filter comprising at least one planar interface, separating a first material having a first refractive index n1 and a second material having a second refractive index n2, the ratio of the second refractive index over the first refractive index being lower than 1, preferably lower than 0.66.

Abstract: A device for optically imaging at least a part of an object, the device having an optical axis and including a two-dimensional first array of first microlenses, having a first side intended to face the object, and a second side, opposite the first side, a two-dimensional second array of second microlenses, each first microlens being aligned with a second microlens on an axis parallel to the optical axis, wherein each first microlens comprises a first catoptric system, and preferably a first catadioptric system.

Abstract: The present invention relates to a multichannel imaging device and more specifically to a multichannel device wherein each optical channel has at least an optical low-pass angular filter configured to block any light propagating through the optical channel along a direction of propagation having an angle which is greater than a predefined angle ?L relative to the optical axis, the low-pass angular filter comprising at least one planar interface, separating a first material having a first refractive index n1 and a second material having a second refractive index n2, the ratio of the second refractive index over the first refractive index being lower than 1, preferably lower than 0.66.