Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.
Type:
Application
Filed:
June 21, 2012
Publication date:
December 20, 2012
Applicant:
DEPOMED, INC.
Inventors:
CHIEN-HSUAN HAN, Sui Yuen Eddie Hou, Monica L. Reid
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Grant
Filed:
July 19, 2012
Date of Patent:
December 18, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
December 18, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core by permitting diffusion of the drug from the core. The shell also motes gastric retention of the dosage form by swelling upon imbibition of gastric fluid to size that is retained in the stomach during the postprandial or fed mode.
Type:
Grant
Filed:
June 8, 2011
Date of Patent:
December 11, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Jenny Louie-Helm, Gloria Gusler, John N. Shell
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Application
Filed:
July 27, 2012
Publication date:
November 15, 2012
Applicant:
DEPOMED, INC.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Application
Filed:
July 19, 2012
Publication date:
November 8, 2012
Applicant:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing lull access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.
Type:
Application
Filed:
June 22, 2012
Publication date:
October 18, 2012
Applicant:
DEPOMED, INC.
Inventors:
JONG LIM, John N. Shell, Jenny Louie-Helm
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Grant
Filed:
November 21, 2011
Date of Patent:
July 31, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Application
Filed:
February 14, 2012
Publication date:
June 14, 2012
Applicant:
DEPOMED, INC.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Grant
Filed:
May 19, 2011
Date of Patent:
June 5, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M Gusler
Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.
Type:
Application
Filed:
January 27, 2012
Publication date:
May 31, 2012
Applicant:
DEPOMED, INC.
Inventors:
Chien-Hsuan Han, Sui Yuen Eddie Hou, Monica L. Reid
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.
Abstract: Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
Type:
Application
Filed:
November 21, 2011
Publication date:
March 15, 2012
Applicant:
DEPOMED, INC.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.
Type:
Grant
Filed:
September 21, 2009
Date of Patent:
February 21, 2012
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.
Type:
Application
Filed:
October 10, 2011
Publication date:
February 2, 2012
Applicant:
DEPOMED, INC.
Inventors:
Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
Abstract: Controlled release oral dosage forms are provided for the continuous, sustained administration of a pharmacologically active agent to the upper gastrointestinal tract of a patient in whom the fed mode as been induced. The majority of the agent is delivered, on an extended release basis, to the stomach, duodenum and upper regions of the small intestine, with drug delivery in the lower gastrointestinal tract and colon substantially restricted. The dosage form comprises a matrix of a biocompatible, hydrophilic, erodible polymer with an active agent incorporated therein, wherein the polymer is one that both swells in the presence of water and gradually erodes over a time period of hours, with swelling and erosion commencing upon contact with gastric fluid, and drug release rate primarily controlled by erosion rate.
Abstract: Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core by permitting diffusion of the drug from the core. The shell also motes gastric retention of the dosage form by swelling upon imbibition of gastric fluid to size that is retained in the stomach during the postprandial or fed mode.
Type:
Grant
Filed:
April 29, 2010
Date of Patent:
October 25, 2011
Assignee:
Depomed, Inc.
Inventors:
Bret Berner, Jenny Louie-Helm, Gloria Gusler, John N. Shell