Abstract: A polyurethane foam wound dressing and a method for making the dressing is described. The dressing is made from the reaction of a polyurethane prepolymer with a difunctional cross-linking agent in the presence of DMEA and substantial amounts of water. The resulting dressing has a glazed, mirror-smooth surface for application to the wounded area and an insular region to maintain the wound at near body temperature. The dressing has a moisture vapor transmission rate that is close to the capacity of the wound surface to produce serous exudate.