Abstract: Formulation for topical application comprising, in percentages by weight on the total weight of the formulation, 0.5%-10% of N-acetylcysteine and 2-30% of urea and a dermatologically acceptable vehicle, for use in the treatment and/or prevention of a condition selected from the group consisting of dermatological disorders of the Sudeck syndrome, chemotherapy-induced palmar-plantar erythrodysesthesia, dermatological disorders caused by radiotherapy and diabetic foot syndrome; the N-acetylcysteine can be in form of a complex with beta-cyclodextrins and is preferably of synthetic origin.