Abstract: Example embodiments of the present invention comprise an analyte sensing patch, comprising a substrate, and a sensing agent disposed on the substrate such that analyte can encounter the sensing agent through a side of the patch disposed adjacent the skin of a subject but not through a side of the patch disposed away from the skin of the subject. Example embodiments of the present invention comprise an analyte sensing patch, comprising a substrate, a sensing material disposed on the substrate in a first region thereof, an adhesive disposed on the substrate in a second region thereof, wherein the second region surrounds the first region, wherein the sensing agent undergoes a change in a discernible characteristic responsive to encounter with a predetermined analyte.