Patents Assigned to DermTech International
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Patent number: 9057109Abstract: The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.Type: GrantFiled: March 6, 2014Date of Patent: June 16, 2015Assignee: DERMTECH INTERNATIONALInventor: Sherman H. Chang
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Publication number: 20150005184Abstract: The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.Type: ApplicationFiled: March 13, 2014Publication date: January 1, 2015Applicant: DermTech InternationalInventors: John P. ALSOBROOK, Tara J. PALMER
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Publication number: 20140323331Abstract: Described herein are methods, systems, platforms, and kits for the characterization, assessment, diagnosis and treatment of acne vulgaris. Among the methods provided are methods of identifying a gene expression profile for acne vulgaris and biomarkers for monitoring treatment. Also provided are methods, systems, platforms, and kits for monitoring efficacy of a treatment and methods for selecting a treatment regimen.Type: ApplicationFiled: April 24, 2014Publication date: October 30, 2014Applicant: DermTech InternationalInventors: Sherman H. Chang, Tara J. Palmer
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Publication number: 20130296185Abstract: The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.Type: ApplicationFiled: March 19, 2013Publication date: November 7, 2013Applicant: DermTech InternationalInventor: DermTech International
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Patent number: 7989165Abstract: The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.Type: GrantFiled: February 23, 2007Date of Patent: August 2, 2011Assignee: DermTech InternationalInventor: Nicholas R. Benson
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Publication number: 20100086501Abstract: The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample and compare them with a known skin age index. Therapeutic and cosmetic formulations are also provided herein.Type: ApplicationFiled: August 28, 2009Publication date: April 8, 2010Applicant: DermTech InternationalInventors: Sherman H. Chang, Gail K. Naughton
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Publication number: 20080274908Abstract: The present invention provides methods for diagnosing melanoma in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.Type: ApplicationFiled: May 2, 2008Publication date: November 6, 2008Applicant: DermTech InternationalInventor: Sherman Chang
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Publication number: 20070281314Abstract: The present invention provides non-invasive methods for isolating an miRNA molecule from an epidermal sample, as well as detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to obtain the miRNA from epidermal samples, and may be used to further analyze expression of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.Type: ApplicationFiled: April 20, 2007Publication date: December 6, 2007Applicant: DERMTECH INTERNATIONALInventor: Nicholas Benson
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Patent number: 7297480Abstract: The present invention provides non-invasive methods for detecting, monitoring, staging, and diagnosing malignant melanoma in a skin sample of a subject. The methods include analyzing expression in skin sample of one or more melanoma skin markers. The melanoma skin markers include IL-1 RI, endothelin-2, ephrin-A5, IGF Binding Protein 7, HLA-A0202 heavy chain, Activin A (?A subunit), TNF RII, SPC4, and CNTF R?. The skin sample can include nucleic acids, and can be a human skin sample from a lesion suspected of being melanoma.Type: GrantFiled: June 27, 2002Date of Patent: November 20, 2007Assignee: Dermtech InternationalInventor: Thomas Vogt
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Patent number: 7183057Abstract: The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.Type: GrantFiled: March 31, 2004Date of Patent: February 27, 2007Assignee: Dermtech InternationalInventor: Nicholas R. Benson
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Publication number: 20050221334Abstract: The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a micro array.Type: ApplicationFiled: March 31, 2004Publication date: October 6, 2005Applicant: DermTech InternationalInventor: Nicholas Benson
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Patent number: 6949338Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.Type: GrantFiled: August 17, 1999Date of Patent: September 27, 2005Assignee: DermTech InternationalInventors: Lawrence A. Rheins, Vera B. Morhenn
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Patent number: 6720145Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.Type: GrantFiled: September 28, 2001Date of Patent: April 13, 2004Assignee: Dermtech InternationalInventors: Lawrence A. Rheins, Vera B. Morhenn