Patents Assigned to DESENTUM OY
  • Recombinant hypoallergenic Equ c 1 polypeptides for use in the immunotherapy of horse allergy
    Patent number: 11679152
    Abstract: The present invention relates to specific modified Equ c 1 polypeptides and to the use of such polypeptides as hypoallergens for desensitizing against horse allergy. Particularly, the present invention provides a recombinant hypoallergenic Equ c 1 polypeptide comprising at least two amino acid modifications compared to a corresponding wild type Equ c 1 allergen, wherein the recombinant hypoallergenic polypeptide activates release of histamine from basophils to a degree less than the wild type allergen.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: June 20, 2023
    Assignee: Desentum Oy
    Inventors: Juha Rouvinen, Kristiina Takkinen, Marja-Leena Laukkanen, Merja Niemi, Janne Jänis, Jaana Haka
  • Hypoallergen
    Patent number: 9856296
    Abstract: The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: January 2, 2018
    Assignee: DESENTUM OY
    Inventors: Kristiina Takkinen, Marja-Leena Laukkanen, Hans Söderlund, Sirpa Jylhä, Heidi Holkeri, Merja Niemi, Janne Jänis, Juha Rouvinen
  • Allergen-binding IgE monoclonal antibodies and method for preparing hypoallergens
    Patent number: 9261511
    Abstract: The present invention relates to human IgE antibodies and derivatives thereof, which bind non-continuous planar allergenic epitope, such as in ?-lactoglobulin, with high affinity and specificity. The present invention also relates to processes for making and engineering such allergen binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics and immunotherapy.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: February 16, 2016
    Assignee: DESENTUM OY
    Inventors: Sirpa Jylhä, Merja Niemi, Juha Rouvinen, Marja-Leena Laukkanen, Kristiina Takkinen, Hans Söderlund, Soili Mäkinen-Kiljunen, Tari Haahtela