Abstract: The present application provides a unique way for storing biologics, perishables, food, drinks in a preservation and transportation system. The portable preservation system comprising a main body comprising an outer shell having at least one docking compartment and a main compartment. A cooling unit placed in the main compartment having a supply line and a return line wherein the supply line is connected to a supply manifold. At least one valve wherein the valve is connected to the supply manifold. At least one supply connection port wherein the supply connection port is coupled to at least one opposing port which supplies coolant to an external system having an inlet and outlet wherein the outlet is connected to at least one return connection port.