Abstract: The disclosure provides modified chloroquine compounds having single ring or fused ring moieties. Also provided are pharmaceutical compositions comprising such compounds, methods of using such compounds to inhibit or treat diseases or conditions caused by chloroquine-resistant (CQR) and chloroquine-sensitive (CqS) malaria parasites and other CQ-susceptible microorganisms, and processes and intermediates useful for preparing such compounds.
Type:
Grant
Filed:
December 4, 2009
Date of Patent:
February 25, 2014
Assignees:
DesignMedix, Inc., Portland State University
Inventors:
David H. Peyton, Steven J. Burgess, Katherine M. Liebman, Bornface Gunsaru
Abstract: The disclosure provides modified chloroquine compounds having single ring or fused ring moieties. Also provided are pharmaceutical compositions comprising such compounds, methods of using such compounds to inhibit or treat diseases or conditions caused by chloroquine-resistant (CQR) and chloroquine-sensitive (CqS) malaria parasites and other CQ-susceptible microorganisms, and processes and intermediates useful for preparing such compounds.
Type:
Application
Filed:
December 4, 2009
Publication date:
October 13, 2011
Applicants:
PORTLAND STATE UNIVERSITY, DESIGNMEDIX, INC.
Inventors:
David H. Peyton, Steven J. Burgess, Katherine M. Liebman, Bornface Gunsaru