Abstract: The invention provides the use of a compound of formula (I), or metallated derivative thereof, for killing, inhibiting or preventing the growth of a microbial biofilm: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description. The biofilm may be on a living or inert support. Preferably, the microorganisms are selected from the group consisting of bacteria and fungi.
Type:
Grant
Filed:
October 23, 2009
Date of Patent:
May 3, 2016
Assignee:
Destiny Pharma Limited
Inventors:
William Guy Love, William Rhys-Williams
Abstract: A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
Type:
Grant
Filed:
November 21, 2006
Date of Patent:
December 27, 2011
Assignee:
Destiny Pharma Limited
Inventors:
William Love, Derek Brundish, William Rhys-Williams, Xiang Dong Feng, Benoit Pugin
Abstract: A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
Type:
Grant
Filed:
December 23, 2003
Date of Patent:
July 17, 2007
Assignees:
Destiny Pharma Limited, Solvias AG
Inventors:
William Love, Derek Brundish, William Rhys-Williams, Xiang Dong Feng, Benoit Pugin
Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
Type:
Grant
Filed:
February 28, 2002
Date of Patent:
March 8, 2005
Assignees:
Destiny Pharma Limited, University of Brighton
Inventors:
Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love
Abstract: There is provided a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y1, Y2, Y3, Z, M, A-B and C-D have meanings given in the description, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Compositions, apparatus and methods of treatment of a medical condition for which a photodynamic compound is indicated are also disclosed.
Type:
Grant
Filed:
April 30, 2001
Date of Patent:
October 7, 2003
Assignees:
Destiny Pharma Limited, University of East Anglia
Inventors:
William Guy Love, Michael John Cook, David Andrew Russell
Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
Type:
Application
Filed:
February 28, 2002
Publication date:
November 7, 2002
Applicant:
DESTINY PHARMA LIMITED
Inventors:
Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love