Abstract: Described herein is a high-energy x-ray imaging system including a stationary gantry, a conveyor assembly configured to convey an object to be imaged through the gantry, a plurality of linear accelerators, a detector array, and a control system. The linear accelerators are arranged in an array within the gantry and are configured to generate high-energy x-ray fan beams to be transmitted through the object. The detector array is positioned opposite the linear accelerators and is configured to collect the high-energy x-ray fan beams transmitted through the object. The control system is configured to energize the linear accelerators according to a predetermined control sequence to generate the high-energy x-ray fan beams, and construct a 3-D image of the object based on data received from the detector array and representative of the high-energy x-ray fan beams transmitted through the object.

Abstract: Provided herein are dye compounds having improved properties, such as aqueous solubility, stability, and fluorescence, as well as methods of detecting the presence or absence of an analyte in a test sample using said dye compounds.

Abstract: The present disclosure provides electron source devices, electron source assemblies, and/or methods for generating electrons. The generated electrons can be used to facilitate spectroscopy, such as mass spectrometry, including mass selection or ion mobility.

Abstract: Radiation source localization systems and related techniques are provided to improve the operation of handheld or unmanned mobile sensor or survey platforms. A radiation source localization system includes a logic device configured to communicate with a communications module and a directional radiation detector, where the communications module is configured to establish a wireless communication link with a base station associated with the directional radiation detector and/or a mobile sensor platform, and the directional radiation detector includes a sensor assembly configured to provide directional radiation sensor data as the directional radiation detector is maneuvered within a survey area.

Abstract: Apparatuses, methods, and systems for generating signatures based on sensing one or more gas concentration conditions are disclosed. One method includes sensing, by one or more sensors, levels of a gas over time for a plurality of gas concentration conditions, receiving, by a controller, the sensed levels of gas over time for the plurality of gas concentration conditions, and generating, by the controller, a plurality of signatures, wherein one or more signatures is generated for one or more gas concentration conditions based on the sensed levels of gas over time, and determining whether to take action or not to take action.

Abstract: Apparatuses, methods, and systems for detecting a sample are disclosed. One method includes generating, by a tunable light source, a beam of electro-magnetic radiation, wherein a wavelength of the beam of electro-magnetic radiation is tuned to operate at a plurality of wavelengths. At least a portion of the beam of electro-magnetic radiation is directed to pass through the sample and a reference substance. The system detector is configured to sense at least the portion of the beam of electro-magnetic radiation after passing through the sample and the reference substance. The processor operates to receive information related to intensity or amplitude of the sensed beam of electro-magnetic radiation after passing through the sample and the reference substance and detect an amount of the sample based on the received information related to the intensity or amplitude of the sensed beam of the electro-magnetic radiation.

Abstract: This specification describes systems for unmanned aerial vehicle carrying and deployment. In some examples, an unmanned vehicle includes a drive system and a chassis. The chassis includes a platform for carrying an unmanned aerial vehicle and a retainer configured to secure the unmanned aerial vehicle to the platform while the drive system drives the unmanned vehicle. The clamping system includes at least a first rotating bar and a protrusion from the first rotating bar.

Abstract: A leak detecting device for a fluid filled vessel including (1) a housing having a continuous perimeter edge sized to extend around an underwater surface; (2) a tube extending through an aperture of the housing, having a first end on an first side of the housing and a second end on a second side of the housing; (3) an anchoring attachment secured to the first end of the tube; (4) a resilient member secured to the perimeter edge of the housing and adapted to contact and form a seal between the housing and the underwater surface; and (5) an opening through an entirety of a wall of the housing, wherein the opening is accessible from the second side of the housing.

Abstract: Apparatuses, methods, and systems for detecting a sample are disclosed. One method includes generating, by a tunable light source, a beam of electro-magnetic radiation, wherein a wavelength of the beam of electro-magnetic radiation is tuned to operate at a plurality of wavelengths. At least a portion of the beam of electro-magnetic radiation is directed to pass through the sample and a reference substance. The system detector is configured to sense at least the portion of the beam of electro-magnetic radiation after passing through the sample and the reference substance. The processor operates to receive information related to intensity or amplitude of the sensed beam of electro-magnetic radiation after passing through the sample and the reference substance and detect an amount of the sample based on the received information related to the intensity or amplitude of the sensed beam of the electro-magnetic radiation.

Abstract: A detection device for detecting the presence of a substance of interest in a sample is described. The device can include a data store comprising executable instructions for at least one convolutional neural network, CNN, configured to process images: and a processor coupled to the data store and configured to execute the instructions to operate the at least one CNN. The detection device can be configured to: obtain spectrometry data, operate a first one of the CNNs to process the spectrometry data to obtain a first CNN output; apply a mask to the spectrometry data to obtain masked data; operate a second one of the CNNs to process the masked data to obtain a second CNN output; and determine if the substance of interest is present in the sample based on both the first CNN output and the second CNN output.

Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.

Abstract: The present disclosure describes Bst polymerase variants which exhibit DNA-dependent DNA polymerase and reverse transcriptase activity, and methods of use thereof. The Bst polymerase variants of the disclosure may be combined with a separate enzyme having reverse transcriptase activity to amplify target RNA sequences; however, the addition of a separate enzyme having reverse transcriptase activity is not necessary for the successful amplification of RNA targets using the Bst polymerase variants of the disclosure. Target DNA sequences may also be amplified using Bst polymerase variants of the disclosure.

Abstract: A method for controlling an unmanned aerial vehicle within a flight operating space. The unmanned aerial vehicle includes one or more sensor arrays on each spar. The method includes determining, using a plurality of sensor arrays, a flight path for the unmanned aerial vehicle. The method also includes receiving, by at least one sensor array of the plurality of sensor arrays, sensor data identifying at least one object in the operating space. The sensor data is transmitted over a communications bus connecting components of the UAV. The method further includes determining, by one or more processors onboard the unmanned aerial vehicle, a flight path around the at least one object. The method also includes generating, by the one or more onboard processors, a first signal to cause the unmanned aerial vehicle to navigate within the operating space around the at least one object.

Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.

Abstract: A method for unmanned delivery of an item to a desired delivery location includes receiving, at an unmanned vehicle, first data representative of an approximate geographic location of the desired delivery location, receiving, at the unmanned vehicle, second data representative of a fiducial expected to be detectable at the desired delivery location, using the first data to operate the unmanned vehicle to travel to the approximate geographic location of the desired delivery location, upon arriving at the approximate geographic location of the desired delivery location, using the second data to operate the unmanned vehicle to detect the fiducial; and upon detecting the fiducial, using the fiducial to operate the unmanned vehicle to deliver the item.

Abstract: A leak detecting device for a fluid filled vessel including a housing, a solid shaft, an anchoring attachment, and a resilient member. The housing has a continuous perimeter edge sized to extend around an underwater surface, forms a hollow interior, and includes a first aperture formed through a wall of the housing and a second aperture formed through the wall of the housing. The solid shaft extends through the first aperture of the housing and has a first end on an interior side of the housing and a second end on an exterior side of the housing. The anchoring attachment is secured to the first end of the solid shaft. The resilient member is secured to the perimeter edge of the housing.

Abstract: In an aspect, in general, a spooling apparatus includes a filament feeding mechanism for deploying and retracting filament from the spooling apparatus to an aerial vehicle, an exit geometry sensor for sensing an exit geometry of the filament from the spooling apparatus, and a controller for controlling the feeding mechanism to feed and retract the filament based on the exit geometry.

Abstract: An unmanned ground vehicle includes a main body, a drive system supported by the main body, a manipulator arm pivotally coupled to the main body, and a sensor module. The drive system includes right and left driven track assemblies mounted on right and left sides of the main body. The manipulator arm includes a first link coupled to the main body, an elbow coupled to the first link, and a second link coupled to the elbow. The elbow is configured to rotate independently of the first and second links. The sensor module is mounted on the elbow.