Abstract: Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and/or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.
Type:
Grant
Filed:
March 26, 2014
Date of Patent:
August 23, 2016
Assignee:
DETERMINANTS OF METABOLISM RESEARCH LABORATORY S.R.L.
Inventors:
Franco Conti, Francesco Saverio Dioguardi
Abstract: Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and/or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.
Type:
Application
Filed:
March 26, 2014
Publication date:
July 24, 2014
Applicant:
DETERMINANTS OF METABOLISM RESEARCH LABORATORY S.R.L.
Inventors:
Franco CONTI, Francesco Saverio DIOGUARDI
Abstract: Compositions based on amino acids are described, for improving the myocardial ventricular function in patients suffering from diabetes, particularly but not exclusively II type diabetes. The compositions according to the invention comprise up to 75% of the branched chain amino acids leucine, isoleucine and valine, as active ingredients. Preferably, the compositions also comprise, as further active ingredients, up to 50% of threonine and lysine. Other essential amino acids are preferably also provided, in particular methionine, phenylalanine, histidine, tryphtophan, as well as non essential amino acids, in particular tyrosine and/or cyst(e)ine (i.e., cystine and cysteine). Other amino acids can be added, provided that their sum is in a percentage being lower than 20% with respect to the other active ingredients, and less than 10% for each single amino acid.
Type:
Grant
Filed:
April 17, 2008
Date of Patent:
February 18, 2014
Assignee:
Determinants of Metabolism Research Laboratory S.R.L.
Inventors:
Franco Conti, Francesco Saverio Dioguardi
Abstract: The present invention relates to compositions suitable for the treatment of pathological conditions distinguished by insufficient or reduced mitochondrial function. The compositions comprise, as principal active ingredients, the amino acids leucine, isoleucine and valine. The compositions may also comprise, as further active ingredients, amino acids threonine and lysine, and optionally, histidine, phenylalanine, methionine, tryptophan, as well as tyrosine and cysteine.
Type:
Grant
Filed:
June 15, 2011
Date of Patent:
December 4, 2012
Assignee:
Determinants of Metabolism Research Laboratory S.r.l.