Abstract: Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described.

Abstract: A method to derive anatomical structures from non-invasive imaging technologies is provided. Non-invasive imaging technologies are computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), surface scans and others. Imaging data obtained by a non-invasive technology is used to create a surface contour. The imaging data is transmitted to a rapid prototyping apparatus as readable data. With this readable data the rapid prototyping apparatus establishes a positive or negative surface model, such as a fixation device, a mask, or a prosthesis, or other instruments for medical purposes.

Abstract: The invention relates to an optical imaging detector for fluorescence and bioluminescence imaging of an imaged object that can be used for tomographic imaging. The optical imaging detector comprises at least one micro-lens array with a plurality of micro-lenses. A photo detector can be located either in the focal plane of the micro-lens array or can be connected to the micro-lens array by a network of optical fibers and be located externally.