Patents Assigned to Deutsches Krebsforschungszentrum
  • METHOD OF FLUORESCENCE-MICROSCOPICALLY IMAGING A STRUCTURE IN A SAMPLE WITH HIGH THREE-DIMENSIONAL SPATIAL RESOLUTION
    Publication number: 20090242801
    Abstract: For imaging a structure in a sample with three-dimensional spatial resolution, a fluorophore is selected which is transferable by means of an optical transfer signal out of a first into a second photochromic state having specific fluorescence properties, and which displays a return rate back into the first photochromic state. The structure is labeled with the fluorophore.
    Type: Application
    Filed: March 30, 2009
    Publication date: October 1, 2009
    Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM, Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Johann ENGELHARDT, Marion LANG, Stefan HELL
  • Method to Inhibit the Propagation of an Undesired Cell Population
    Publication number: 20090226446
    Abstract: Disclosed is a method for inhibiting the propagation of an undesired cell population, the method comprising introducing into a cell an antagonist of Bat 3, or of a functional variant thereof, said antagonist depleting Bat 3, a functional variant thereof, in a cell of said cell population, and verifying the reduced proliferation and/or cell death in Bat 3 depleted cell populations; disclosed is further the use of a Bat 3 antagonist for the manufacture of a medicament for the treatment of diseases which are caused by the propagation of an undesired cell population.
    Type: Application
    Filed: April 5, 2007
    Publication date: September 10, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des offentilchen Rechts
    Inventors: Celina Cziepluch, Jean Rommelaere, Marc Winnefeld
  • ANTIBODIES ACTIVE AGAINST A FUSION POLYPEPTIDE COMPRISING A HISTIDINE PORTION
    Publication number: 20090221040
    Abstract: The present invention relates to an antibody active against a fusion polypeptide comprising a histidine portion, a process for the preparation thereof and its use.
    Type: Application
    Filed: May 14, 2009
    Publication date: September 3, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Hanswalter ZENTGRAF, Claudia TESSMER, Iris VELHAGEN, Susanne SCHWINN, Manfred FREY
  • Diagnosis and Therapy of Cell Proliferative Disorders Characterized by Resistance to Trail Induced Apoptosis
    Publication number: 20090203587
    Abstract: Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described.
    Type: Application
    Filed: October 10, 2005
    Publication date: August 13, 2009
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFE
    Inventors: Stephan Wolf, Stefan Joss, Daniel Mertens, Armin Pscherer, Peter Lichter
  • PNA conjugate for the treatment of diseases associated with HIV
    Patent number: 7563761
    Abstract: The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of HIV. The conjugates comprise the following components: (a) a transport mediator for the cell membrane, (b) an address protein or peptide for the import into the cell nucleus, and (c) a peptide nucleic acid (PNA) which is to be transported and can be hybridized with an HIV gene and can inhibit the expression of the HIV gene.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: July 21, 2009
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Klaus Braun, Waldemar Waldeck, Rudiger Pipkorn, Isabell Braun, Jurgen Debus
  • Method of selecting a desired protein from a library
    Publication number: 20090162841
    Abstract: Described is an improved method of selecting a member of a specific binding pair (sbp) having a desired specify, preferably an antibody, from a library expressing said member of a sbp, preferably a phage-display antibody library.
    Type: Application
    Filed: August 3, 2005
    Publication date: June 25, 2009
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTING DES OFFENTLICHEN RECHTS
    Inventor: Jorg Hoheisel
  • Peptides for inducing apoptosis in tumor cells
    Patent number: 7544768
    Abstract: The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present invention release tumor cells from the apoptosis block and thus provide a new tool for effective cancer therapy.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: June 9, 2009
    Assignee: Deutsches Krebsforschungszentrum Stiflung des Offentlichen Rechts
    Inventors: Karin Hoppe-Seyler, Felix Hoppe-Seyler, Irena Crnkovic-Mertens, Christian Rausch
  • Riproximin, a Novel Type II Ribosome-Inactivating Protein and Uses Thereof
    Publication number: 20090137502
    Abstract: Described is a novel type II ribosome-inactivating protein, riproximin, as well as nucleic acid molecules encoding said protein. Furthermore, therapeutic uses of riproximin are described.
    Type: Application
    Filed: February 6, 2006
    Publication date: May 28, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
    Inventors: Cristina Voss, Martin Berger, Carlos Schumacher
  • Diagnostic conjugate useful for intracellular imaging and for differentiating between tumor- and non-tumor cells
    Patent number: 7531502
    Abstract: Described is a diagnostic conjugate comprising (a) a transmembrane module (TPU), (b) an address module (AS), preferably an antisense peptide nucleic acid (PNA), and (c) a signaling module (SM). The conjugate is useful for intracellular imaging, preferably via MRI, and, e.g., for differentiating between tumor- and non-tumor cells.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: May 12, 2009
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
    Inventors: Klaus Braun, Jürgen Debus, Jürgen Jenne, Rudiger Pipkorn, Ralf Rastert, Waldemar Waldeck, Isabell Braun, Stefan Heckl
  • Means and Methods for Treating Advanced Stage Neuroblastoma
    Publication number: 20090082258
    Abstract: The present invention relates to uses of compounds having a structure as shown by formula (I) for the manufacture of a pharmaceutical composition for the treatment of neuroblastoma. Moreover, the present invention encompasses methods of treatment for said diseases.
    Type: Application
    Filed: December 15, 2006
    Publication date: March 26, 2009
    Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG
    Inventors: Olaf Witt, Hedwig Elisabeth Deubzer, Frank Westermann, Gabi Roenndahl, Ralf Heinrich, Volker Ehemann
  • Collimator for Defining a Beam of High-Energy Rays
    Publication number: 20090074148
    Abstract: The invention relates to a collimator (1) for limiting a beam of high-energy radiation (2) which, starting from an essentially point-shaped radiation source (3), is directed onto an object (4) to be treated and which is used especially for stereotactic, conformal radiation therapy of tumors, wherein the collimator (1) has an iris diaphragm (5) as a beam-limiting means.
    Type: Application
    Filed: August 10, 2005
    Publication date: March 19, 2009
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM-STIFTUNG DESÖFFEN
    Inventor: Gernot Echner
  • Inverse Treatment Planning Method
    Publication number: 20090060130
    Abstract: The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a biological system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights wj within the target.
    Type: Application
    Filed: February 2, 2007
    Publication date: March 5, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
    Inventors: Jan Wilkens, Uwe Oelfke
  • Dual-modality imaging
    Publication number: 20090039268
    Abstract: The invention relates to a dual-modality imaging system and a method for dual-modality imaging, wherein a positron emission tomography (PET) scanner for acquiring PET imaging data and at least one optical imaging detector for acquiring optical imaging data are arranged to acquire the PET imaging data and the optical imaging data of an imaged object (5) simultaneously (i.e. at the same time and at superimposed fields-of-view). The at least one optical imaging detector is a non-contact optical imaging detector.
    Type: Application
    Filed: April 10, 2006
    Publication date: February 12, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
    Inventors: Jorg Peter, Ralf Schulz
  • Optical imaging detector
    Publication number: 20090032714
    Abstract: The invention relates to an optical imaging detector for fluorescence and bioluminescence imaging of an imaged object that can be used for tomographic imaging. The optical imaging detector comprises at least one micro-lens array with a plurality of micro-lenses. A photo detector can be located either in the focal plane of the micro-lens array or can be connected to the micro-lens array by a network of optical fibres and be located externally.
    Type: Application
    Filed: April 10, 2006
    Publication date: February 5, 2009
    Applicant: Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
    Inventors: Jorg Peter, Ralf Schulz, Daniel Unholtz
  • Immunogenic compositions comprising HIV-1 acetylated Tat polypeptides
    Patent number: 7482016
    Abstract: The present invention provides compositions, including immunogenic compositions, comprising acetylated Tat protein of an immunodeficiency virus. The present invention further provides antibodies that specifically bind an acetylated Tat polypeptide. The present invention further provides methods of inducing an immune response to an immunodeficiency virus Tat protein in an individual. The present invention further provides methods of inhibiting transcriptional activation of an immunodeficiency virus in a cell of an individual.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: January 27, 2009
    Assignees: The J. David Gladstone Institutes, Deutsches Krebsforschungszentrum
    Inventors: Alexander P. Doerr, Melanie Ott, Eric Verdin
  • Conjugate for treating prokaryotic infections
    Patent number: 7476658
    Abstract: The invention relates to a conjugate for treating prokaryotic infections from a transport mediator penetrating the prokaryotic cell membrane and a desired compound to be introduced into the prokaryote and directed thereagainst, which compound is preferably a peptide nucleic acid (PNA) directed against a gene of the prokaryote giving antibiotic resistance.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: January 13, 2009
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Klaus Braun, Isabell Braun, Jürgen Debus, Rudiger Pipkorn, Waldemar Waldeck
  • Device and Method for Creating a Spatial Dose Distribution in a Medium Volume
    Publication number: 20080298401
    Abstract: A device and a method for creating a spatial dose distribution in a medium volume (22) are described. A laser system produces laser pulses (12) with a pulse length shorter than 200 fs (femtoseconds) and is capable to be focused to peak intensities greater than 10?18 W/cm?2 (watts per centimeter squared). An electron source (18) is capable of releasing a high-energy electron pulse (20), in particular the electrons having an energy greater than 100 MeV, upon irradiation with said laser pulses (12) propagating into the medium volume (22). The light paths (52, 56,58) of at least some of the laser pulses (12) are adjustable in such a way that high-energy electron pulses (20) are emitted from the irradiated at least one electron source on different trajectories (20,28,60,62) through the medium volume (22) thereby depositing their dose in the medium volume (22) according to a provided pattern.
    Type: Application
    Filed: July 20, 2006
    Publication date: December 4, 2008
    Applicants: ECOLE POLYTECHKNIQUE, DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Jerome Faure, Yannick Glinec, Malka Victor, Thomas Fuchs, Hanitra Szymanowski, Uwe Oelfke
  • Use of Dmbt1 for Capturing Sulphate and Phosphate Group Exposing Agents
    Publication number: 20080234185
    Abstract: Disclosed is the use of DMBT1, or of the nucleic acid encoding it, for the manufacture of a medicament for the treatment of a patient suffering from a disease caused by an agent, which possesses at least one accessible sulphate and/or at least one accessible phosphate group, uses of DMBT1 as a diagnostic for diagnosing the susceptibility of an individual to sulphate or phosphate groups, as well as methods for diagnosis, prophylaxis or treatment of diseases caused by an agent which possesses at least one accessible sulphate and/or at least one accessible phosphate group.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 25, 2008
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Jan Mollenhauer, Caroline End, Stephanie Blaich, Gaby Bergmann, Marcus Renner, Stefan Lyer, Rainer Wittig, Annemarie Poustka, Floris Bikker, Antoon Ligtenberg, Arie Nieuw-Amerongen, Enno Veerman
  • Implantable Chamber, Imaging Method and Magnetic Resonance Imaging System
    Publication number: 20080139927
    Abstract: The present invention relates to an implantable chamber (1) with a connecting element (2), comprising a connecting sleeve (6) and a surrounding contact surface (7), an insert element (3), comprising an insert sleeve (8) and a surrounding abutment surface (9). The insert sleeve (8) is inserted into the connecting sleeve (6) of the connecting element (2). The implantable chamber (1) further comprises a cap (4) with a surrounding edge (11), the cap (4) partly covering the connecting element (2) and the insert element (3), leaving an opening (13) on one side. The implantable chamber (1) contains a passive resonance circuit (14) with an inductance and a capacitance, the passive resonance circuit (14) surrounding at least part of a cavity (15) inside the insert element (3).
    Type: Application
    Filed: January 10, 2006
    Publication date: June 12, 2008
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG
    Inventors: Michael Bock, Reiner Umathum, Norbert Fusenig, Margaretha Muller, Fabian Kiessling
  • DIAGNOSTIC AND THERAPEUTIC METHODS BASED ON THE L1 ADHESION MOLECULE FOR OVARIAN AND ENDOMETRIAL TUMORS
    Publication number: 20080138331
    Abstract: A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
    Type: Application
    Filed: October 2, 2007
    Publication date: June 12, 2008
    Applicants: Mor Research Applications, Ltd., Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Peter Altevogt, Mina Fogel