Patents Assigned to Deutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts
  • Patent number: 6485929
    Abstract: The invention relates to a method for inhibiting CD95-independent apoptosis, comprising the following steps: (a) blocking the bonding of HIV-1 gp120 on receptors CD4 and/or CXCR4 or of a factor competing for this bonding, and/or (b) inhibiting the signal path induced by the bonding of (a). The invention also relates to a system for identifying substances which can be utilized for inhibiting CD95-independent apoptosis.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: November 26, 2002
    Assignee: Deutsches Krebsforschungzentrum Stiftung des offentlichen Rechts
    Inventors: Peter Krammer, Christina Berndt
  • Patent number: 6417339
    Abstract: The invention relates to dendrimers comprising an initiator core with at least two functional groups and at least two saccharides, a process for preparing sch dendrimers as well as uses thereof.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 9, 2002
    Assignee: Deutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts
    Inventors: Manfred Wiessler, Markus Gschrey, Willi Von der Lieth, Walter Mier
  • Patent number: 6025163
    Abstract: This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof and the use thereof in diagnosis, treatment and vaccination.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: February 15, 2000
    Assignee: Deutsches Krebsforschungzentrum Stiftung Des Offentlichen Rechts
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Irene Leigh, Harald Zur Hausen
  • Patent number: 5952169
    Abstract: The present invention relates to a DNA construct containing a cDNA sequence for human poly(ADP-ribose)-polymerase, cell lines containing the DNA construct, and a process for identifying DNA-damaging substances by means of these cell lines which overexpress poly(ADP-ribose)-polymerase.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: September 14, 1999
    Assignee: Deutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts Im Neuenheimer Feld 280
    Inventors: Alexander Burkle, Leon Van Gool, Jan-Heiner Kupper, Harald Zur Hausen
  • Patent number: 5358515
    Abstract: The antenna system of the invention is insulated on the outside and when inserted in a dissipative medium has a fixed complex resistance. When the antenna is supplied with HF energy through a coaxial cable, only that area of the medium immediately around the antenna is heated. The area surrounding the insulated HF feed line is not heated, or such heating is negligible, since, owing to the fixed complex resistance of the antenna in the medium, any return of energy along the feed line is prevented. The antenna system of the invention is suitable for use in the tumor-therapy field as a hyperthermic microwave applicator for limited local heating of cancerous tissue.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: October 25, 1994
    Assignee: Deutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts
    Inventors: Willibald Hurter, Fritz Reinbold