Abstract: The present invention relates to a method of producing a polyomavirus or polyomavirus-derived virus-like particle (vlp) carrying on its surface at least one targeting molecule that binds to a cell of interest. Furthermore, the present invention relates to a composition comprising such a polyomavirus or polyomavirus-derived vlp and to the use of the polyomavirus or polyomavirus-derived vlp of the invention or the composition of the invention for use as a medicament. The present invention further relates to a kit comprising the polyomavirus or polyomavirus-derived vlp or the composition of the invention.
Type:
Grant
Filed:
February 1, 2018
Date of Patent:
April 13, 2021
Assignee:
Deutsches Primatenzentrum GmbH Leibniz-Institut für Primatenforschung
Inventors:
Jens Gruber, Stefan Schneider, Ellen Eckermann-Felkl, Alina Mosblech, Arnd Steuernagel, Dennis Wegener, Julian Plaga
Abstract: The invention relates to the novel use of gene markers in a method of predicting the risk of or diagnosing a subject to develop graft versus host reaction (GvHR) or graft versus host disease (GvHD). In other aspects the invention also relates to methods of monitoring the efficacy of treatment of GvHR or GvHD, and methods of screening a candidate substance for the treatment of GvHR or GvHD.
Type:
Application
Filed:
December 14, 2011
Publication date:
December 19, 2013
Applicants:
UNIVERSITY OF NEWCASTLE UPON TYNE, GEORG-AUSUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS, UNIVERSITATSMEDIZIN, DEUTSCHES PRIMATENZENTRUM GMBH
Inventors:
Ralf Dressel, Anne Dickinson, Bent Rolstadt, Lutz Walter
Abstract: The invention concerns new virus-like particles composed of the VP1 protein of the JC virus, a process for their production and their use in analytical, diagnostic and therapeutic methods.
Type:
Grant
Filed:
July 17, 1998
Date of Patent:
May 29, 2001
Assignee:
Deutsches Primatenzentrum
Inventors:
Wolfgang Lüke, Gerhard Hunsmann, Thomas Weber
Abstract: A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: ##STR1## wherein X is an azido group, a methoxy radical or a fluorine atom and B is thymine, uracil, guanine, cytosine, purine or hypoxanthine if X is methoxy or fluorine, and B is guanine, purine or hypoxanthine if X is azido or a pharmaceutically acceptable salt thereof. Also disclosed are compositions and compounds useful in the method.
Type:
Grant
Filed:
April 22, 1987
Date of Patent:
November 14, 1989
Assignees:
Max-Planck-Gesellschaft zur Foederung der Wissenschaften e.V., Deutsches Primatenzentrum GmbH
Inventors:
Fritz Eckstein, Gerhard Hunsmann, Heinz Hartmann