Abstract: The invention relates to vaccine preparations, pharmaceutical preparations and methods for inducing protective immunity in humans using a live, attenuated yellow fever virus of strain D17 preferably administered by an intranasal route of administration. The inventors have also developed an assay for detecting the induction of both the binding and neutralizing antibodies formed in a protective immune response in humans who have received an intranasal vaccine preparation of the kind described.
Type:
Grant
Filed:
June 22, 2000
Date of Patent:
January 8, 2002
Assignee:
Deutsches Primatenzentrumg GmbH
Inventors:
Matthias Niedrig, Christiane Stahl-Hennig, Gerhard Hunsmann